| 加味小承气汤对慢性肝损伤大鼠肠源性内毒素血症的影响 |
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| 引用本文： | 高连印,付修文,谭勇,杜宇琼,车念聪. 加味小承气汤对慢性肝损伤大鼠肠源性内毒素血症的影响[J]. 中国中医药信息杂志, 2008, 15(11): 33-34 |
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| 作者姓名： | 高连印 付修文 谭勇 杜宇琼 车念聪 |
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| 作者单位： | 首都医科大学中医药学院,北京,100069 |
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| 基金项目： | 北京市跨世纪优秀人才培养计划 |
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| 摘 要： | 目的探讨加味小承气汤对大鼠肝损伤内毒素血症的作用机制。方法建立硫代乙酰胺（TAA）所致大鼠肝损伤内毒素血症模型，以加味小承气汤进行干预，通过血液生化及病理检查，观察其对内毒素血症大鼠肝功能、肿瘤坏死因子（TNF-α）、内毒素的影响。结果加味小承气汤能明显降低TNF-α、内毒素的含量，减轻肝细胞坏死程度，与模型组比较差异有统计学意义（P〈0．05，P〈0．01）。结论加味小承气汤使内毒素含量、TNF—α水平降低是其对TAA所致大鼠肝损伤具有防护作用的机制之一。
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| 关 键 词： | 加味小承气汤 慢性肝损伤 内毒素血症 大鼠 |
Effect of Jiawei Xiaochengqi Decoction on Intestinal Endotoxemia of Chronic Hepatic Injury Rats |
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| GAO Lian-yin,FU Xiu-wen,TAN Yong,et al. Effect of Jiawei Xiaochengqi Decoction on Intestinal Endotoxemia of Chronic Hepatic Injury Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2008, 15(11): 33-34 |
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| Authors: | GAO Lian-yin FU Xiu-wen TAN Yong et al |
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| Affiliation: | GAO Lian-yin,FU Xiu-wen,TAN Yong,et al (College of TCM , Pharmacy,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Objective To study the therapeutic effect and mechanism of Jiawei Xiaochengqi Decoction on hepatic injures by endotoxin in rats. Methods Endotoxemia model of Wistar rats was made by thioacetamide. Blood biochemistry and pathological changes were examined to observe the effect of Jiawei Xiaochengqi decoction on liver function, TNF-α, endotoxin of the model rats. Results Jiawei Xiaochengqi Decoction could reduce the contents of TNF-α, endotoxin in the blood and the degree of hepatic cells necrosis of Wistar rats. There was significant difference compared with model group （P〈0.05, P〈0.01）. Conclusion Jiawei Xiaochengqi Decoction has protective effect on TAA-induced hepatic injury by decreasing endotoxin and TNF-α. |
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| Keywords: | Jiawei Xiaochengqi Decoction chronic hepatic injury endotoxemia rat |
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