Effect of dose on bioavailability of oral digoxin |
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Authors: | H R Ochs G Bodem D J Greenblatt |
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Institution: | (1) Medizinische Universitätsklinik, Bonn, Federal Republic of Germany;(2) Division of Clinical Pharmacology, Tufts University School of Medicine and New England Medical Center Hospital, Boston, USA |
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Abstract: | Summary Nine healthy volunteers received single 0.25, 0.5, 1.0, 1.5, and 2.0 mg doses of oral digoxin tablets in random sequence on five occasions separated by at least 4 weeks. Urinary excretion of immunoassayable digoxin was determined from 8 consecutive 24 h urine samples collected after each dose. Mean values of cumulative urinary excretion of digoxin at the 5 doses were: 40.9, 35.6, 36.4, 34.1, and 33.5% of the dose (F=0.64; d. f.=4.32; N. S.). Mean values of urinary excretion half-life were: 2.48, 2.03, 2.20, 2.07, and 1.87 days (F=2.87; d. f.=4.32;p=0.05). Thus, the bioavailability of orally administered digoxin tablets in healthy volunteers is dose-independent over an 8-fold range of doses.Supported in part by the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, Federal Republic of Germany; by Sandoz Studienstiftung, Basel, Switzerland; and by Grant MH-12279 from the United States Public Health Service |
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Keywords: | digoxin bioavailability dose-dependency urinary excretion healthy volunteers |
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