柴芍承气汤对腑实热结型中重度急性胰腺炎的预后和炎症反应影响 |
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作者单位: | ;1.张家港市中医医院脾胃病科 |
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基金项目: | Zhangjiagang municipal commission of health and family planning system youth science and technology project in 2018 |
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摘 要: | 目的:探讨柴芍承气汤治疗腑实热结型中重度急性胰腺炎的疗效和对炎症反应的影响,为临床治疗和预后评价提供新思路。方法:选取腑实热结型中重度急性胰腺炎患者60例为研究对象,随机分为常规治疗的对照组和常规治疗联合柴芍承气汤治疗的治疗组,均治疗2周。对比两组临床疗效和中医证候的差异,记录治疗前后Ranson评分、Balthazar CTSI评分、SIRS评分、改良Marshall评分的变化,比较治疗前后炎症因子和氧化应激相关分子的水平。结果:治疗后,对照组和治疗组临床疗效总有效率分别为80.0%和93.3%,差异具有统计学意义(χ~2=8.845,P=0.027);治疗后,对照组和治疗组中医证候评价总有效率分别为76.7%和93.3%,差异具有统计学意义(χ~2=10.024,P=0.012);治疗后,两组Ranson评分、Balthazar CTSI评分、SIRS评分、改良Marshall评分均显著降低(P<0.05),且治疗组降低幅度更大(P<0.05);治疗后,两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和丙二醛(MDA)均显著降低,超氧化物歧化酶(SOD)显著升高(P<0.05),且治疗组改善程度更大(P<0.05)。结论:柴芍承气汤对腑实热结型中重度急性胰腺炎具有较好的疗效,可有效改善炎症反应和氧化应激,具有较高的临床推广意义。
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关 键 词: | 柴芍承气汤 中重度急性胰腺炎 炎症反应 预后 |
Effect of ChaishaoChengqi Decoction on inflammation and prognosis of moderate and severe acute pancreatitis of heat stagnation and Fu-organ excess type |
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Affiliation: | Department of Spleen and Stomach Diseases, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang 215600, China;Department of Spleen and Stomach Diseases, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang 215600, China;Department of Spleen and Stomach Diseases, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang 215600, China |
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