丙二醛和超氧化物歧化酶与白内障

本文采用荧光光度法和比色法测定了30只老年性、22只并发性白内障晶体和22只透明晶体的丙二醛(MDA)和超氧化物歧化酶(SOD),同时测定了30例老年性白内障、22例并发白内障病人血中红细胞MDA、SOD.结果显示:老年性及并发性白内障晶体MDA比透明晶体高,SOD比透明晶体低,老年性、并发性白内障病人晶体中MDA、SOD与其血中MDA、SOD不存在直线相关.透明晶体中MDA与SOD呈负相关而老年性、并发性白内障晶体中MDA与SOD无明显相关关系.上述结果支持脂质过氧化及抗氧自由基防御系统在白内障发病机理中的作用.

MALONALDEHYDE, SUPEROXIDE DISMUTASE AND HUMAN CATARACT

UV-spectrophotometry and fluorometry were used to study Malonaldehyde(MDA) and Superoxide Dismutase ( SOD) in normal,cataractous human lenses and red blood cells of the patients with cataract. MDA content of senile and complicated cataractous lenses was significantly higher than that of normal human lenses, while that of complicated cataract was significantly higher than that of senile cataract. SOD activity of senile and complicated cataractous lenses was significantly lower than that of normal human lenses, while there was no marked difference between senile and complicated cataractous lenses. Significant correlation between cataractous lenses and red blood cells was not found in MDA content and SOD activity. There was a negative correlation between SOD and MDA in normal human lenses, but no correlation between SOD and MDA in cataractous lenses. The study shows that lipid peroxidation may be one of the possible mechanisms of cataractogenesis in human, and emphasizes the role of SOD in prevention of photoperoxidative damages to the tissues.