How to calculate the quantity of CD34+ cells infused? A single center cohort study based on actual,ideal or adjusted ideal body weight |
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Authors: | Pervin Topcuoglu Ender Akcaglayan Soydan Fuat Ekiz Erol Ayyildiz Klara Dalva Muhit Ozcan Onder Arslan Mutlu Arat Osman Ilhan |
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Affiliation: | Ankara University, Faculty of Medicine, Department of Hematology, Hemapheresis and Blood Bank, Cebeci Kampüsü, 06590 Dikimevi, Ankara, Turkey. |
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Abstract: | Transplant physicians are generally using the recipient's actual body weight (ABW) for the calculation of the content of CD34+ cells in the harvest material in hematopoietic stem cell transplantation (HSCT). As a reference center performing both the stem cell collection and HSCTs, we aimed to evaluate whether there were any differences for neutrophil recovery by calculating the CD34+ cell content in the graft according to actual, ideal (IBW) or adjusted IBW (AIBW) of the recipients in both autologous (n=148) and allogeneic stem cell collection setting (n=234). We observed a negative correlation between the neutrophil recovery and the cell doses infused as to each of these BWs in the allo-HSCT group, but not in the auto-HSCT group. This negative correlation was stronger for IBW and AIBW rather than for ABW in allo-HSCT group. In addition, calculations for both IBW and AIBW in autologous and allogeneic transplants revealed a significant difference in comparison to ABW for different cut-off values of infused CD34+ cells. Consequently, we suggested that both IBW and AIBW based calculations of CD34+ cells infused are better predictors of neutrophil recovery in comparison to ABW in allo-HSCT. We were not able to show this impact in autologous transplants. |
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