| 基质金属蛋白酶-9与神经系统疾病 |
| |
| 引用本文： | 张晓蕴,李小刚. 基质金属蛋白酶-9与神经系统疾病[J]. 中国临床神经科学, 2008, 16(3): 312-317 |
| |
| 作者姓名： | 张晓蕴 李小刚 |
| |
| 作者单位： | 泸州医学院神经内科,646000 |
| |
| 摘 要： | 基质金属蛋白酶-9（MMP-9）是一种Zn^2＋依赖性蛋白水解酶，能降解和重塑细胞外基质，破坏血脑屏障，介导炎症反应，促进神经细胞死亡，同时也有利干运动功能的恢复。MMP-9激活和调控与神经系统疾病的发病机制有密切的关系。MMP-9是研究过程中发现的新靶点，为神经系统疾病的早期诊断、并发症的预防和治疗开辟了新的途径，为神经系统疾病患者的治疗带来曙光。
|
| 关 键 词： | 基质金属蛋白酶 脑缺血 肌萎缩性侧索硬化 多发性硬化 脊髓病 脑炎 帕金森病 阿尔茨海默病 |
| 文章编号： | 1008-0678(2008)03-0312-06 |
| 修稿时间： | 2007-11-02 |
Matrix Metalloproteinase-9 and Neurologic Disease |
| |
| ZHANG Xiao-Yun,LI Xiao-Gang. Matrix Metalloproteinase-9 and Neurologic Disease[J]. Chinese Journal of Clinical Neurosciences, 2008, 16(3): 312-317 |
| |
| Authors: | ZHANG Xiao-Yun LI Xiao-Gang |
| |
| Affiliation: | ( Department of Neurology, The Affiliated Hospital of Luzhou Medical collage, Luzhou 646000, China) |
| |
| Abstract: | Matrix metalloproteinases-9(MMP-9) is a zinc-dependent endopeptidase that participates in degrading and remoding extracellular matrix,destructing the blood-brain barrier,promoting inflammation, finally leads to neuron apoptosis and locomotor recovery.Its activation and regulation are closely correlated with the pathogenesis of neurologic disease.Through these studies new approaches in the early diagnosis,prevention and treatment can be found. |
| |
| Keywords: | matrix metalloproteinases-9 cerebral ischemia amyotrophic lateral sclerosis multiple sclerosis myelopathy encephalitis Parkinson's disease Alzheimer's disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
