老年子宫内膜癌患者临床病理分析及孕激素治疗对预后的作用

Objective To retrospectively analyze clinicopathological features and prognosis effect of progesterone therapy in elderly patients with endometrial carcinoma. Methods Two hundred and thirty-five patients were divided into three groups according to age: 30-49 years old group (n=54), 50-59 years old group (n= 102) and 60-82 years old group (n= 79). The relationship between age and clinicopathological features was analyzed, and the prognosis effect of progesterone therapy in patients of 60-82 years old was assesed. Results The incidences of special pathological type of endometrial cancer (serous eystadenocarcinoma, clear cell carcinoma and squamous cell carcinoma) , operation-pathological stage ≥Ⅲ and low differentiation were increased with advancing age. The incidences of the above mentioned special pathological type of endometrial cancer were 20.4% (11/54), 38. 2%(39/63), 48.1%(38/79) in the three groups, respectively, and there were statistical significances among the three groups (χ<'2> = 10.039, P<0.01). The positive rate of progesterone receptor was significantly decreased in the three groups (57.4% (31/54)vs. 45.1% (46/ 102) vs. 25.3%(20/79), P<0. 01]. The remission rate of progesterone therapy was higher (18/23) than that of radiotherapy and (or) chemotherapy (4/8) (78.3% vs. 50%, Z= 1.46, P<0. 05). Conclusions The incidence of clinical pathological factors of endometrial cancer is increased with advancing age, and the prognosis of progesterone therapy is better than treatment with radiotherapy and (or) chemotherapy.

The analysis of clinicopathological features and of progesteron effect on prognosis in elderly patients with endometrial carcinoma