Diuretic, anti-inflammatory, and analgesic activities of the ethanol extract from Cynoglossum lanceolatum |
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Authors: | Yu Cheng-Hao Tang Wei-Zhong Peng Cheng Sun Tao Liu Bin Li Min Xie Xiao-Fang Zhang Hong |
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Affiliation: | a Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China b Department of Stomatology, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China c Sichuan Good Doctor Pharmaceutical Group, Chengdu 610031, PR China d Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China |
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Abstract: | Ethnopharmacological relevanceCynoglossum lanceolatum Forsk. (Boraginaceae) has been used in folk medicine in china to treat acute nephritis, periodontitis, acute submandibular lymphadenitis, snake bite, etc. However, there have been no scientific reports in the modern literature on the diuretic, anti-inflammatory and analgesic effects of this plant. The objective of this study is to evaluate the above activities of the Cynoglossum lanceolatum extract (CLE) in animals.Materials and methodsThe diuretic effect of CLE was assessed in rats and rabbits. The anti-inflammatory activity was evaluated using fresh egg white-induced paw edema in rats, carrageenan-elicited paw edema in adrenalectomized rats, and dimethylbenzene-induced inflammation in mice. The analgesic action was estimated in mice using the acetic acid-induced writhing test and the hot-plate test. In addition, the acute oral toxicity of CLE was studied in mice.ResultsCLE strikingly and dose-dependently increased urine output of rats and rabbits, suppressed fresh egg white-induced paw edema in rats and carrageenan-elicited paw edema in adrenalectomized rats, reduced dimethylbenzene-induced ear edema in mice, inhibited the writhing response in mice, but did not increased reaction time of mice in the hot-plate test. No death of mice was observed when orally administered CLE up to 12 g/kg.ConclusionsThese findings propose that CLE has evident diuretic, anti-inflammatory, and non-central analgesic activities. Furthermore the anti-inflammatory action does not rely on endogenetic glucocorticoids regulated by hypothalamo-pituitary-adrenal axis. On the other hand, CLE also shows a favorable safety. |
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Keywords: | Cynoglossum lanceolatum Diuretic Anti-inflammatory Analgesic Acute toxicity |
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