Effect of fermented Panax ginseng extract (GINST) on oxidative stress and antioxidant activities in major organs of aged rats |
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Authors: | Ramesh Thiyagarajan Kim Sung-Won Sung Jong-Hwan Hwang Seock-Yeon Sohn Sang-Hyon Yoo Sung-Kwang Kim Si-Kwan |
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Institution: | a Department of Applied biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju-si 380-701, Republic of Koreab IL HWA Co. Ltd. Ginseng Research Institute, 437, Guri-si, Gyeonggi-do 471-711, Republic of Koreac Department of Biomedical Laboratory Science College of Applied Science and Industry, Daejeon University, Daejeon-si 300-716, Republic of Korea |
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Abstract: | The intracellular levels of oxidant and antioxidant balances are gradually distorted during the aging process. An age associated elevation of oxidative stress occurring throughout the lifetime is hypothesized to be the major cause of aging. The present study was undertaken to evaluate the putative antioxidant activity of the fermented Panax ginseng extract (GINST) on lipid peroxidation and antioxidant status of major organs of aged rats compared to young rats. Increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea and creatinine were observed in the serum of aged rats. Increased levels of malondialdehyde (MDA) and significantly lowered activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST) were observed in the liver, kidneys, heart and lungs of aged rats, when compared with those in young rats. Quantitative analysis of the non-enzymatic antioxidants such as reduced glutathione (GSH), ascorbic acid and α-tocopherol levels showed significantly lower values in the liver, kidneys, heart and lungs of aged rats. On the other hand, administration of the fermented Panax ginseng extract (GINST) to aged rats resulted in increased activities of SOD, CAT, GPx, GR and GST as well as elevation in GSH, ascorbic acid and α-tocopherol levels. Besides, the level of MDA, AST, ALT, urea and creatinine were reduced on administration of GINST to aged rats. These results suggested that treatment of GINST can improve the antioxidant status during aging, thereby minimizing the oxidative stress and occurrence of age-related disorders associated with free radicals. |
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Keywords: | Antioxidants Lipid peroxidation Fermented Panax ginseng Aging Oxidative damage |
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