| 肝受体显像剂~(99m)Tc-NGA的制备及临床前研究 |
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| 引用本文： | 孔令山,徐登仁,潘文舟,褚建雄,李鸿勋.肝受体显像剂~(99m)Tc-NGA的制备及临床前研究[J].第二军医大学学报,1992(1). |
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| 作者姓名： | 孔令山 徐登仁 潘文舟 褚建雄 李鸿勋 |
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| 作者单位： | 长海医院核医学科 200433
(孔令山，徐登仁，潘文舟)，第二军医大学训练部化学教研室 200433
(褚建雄)，第二军医大学训练部化学教研室 200433(李鸿勋) |
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| 摘 要： | ~(99m)Tc标记的拟糖蛋白(~(99m)Tc-NGA)是一种新的肝受体显像配基。用化学方法合成的该配基无菌无热原,无毒副作用,有较好的体内体外稳定性。10只家兔分为对照组(6只)、肝门静脉结扎组(2只)和肝坏死组(2只)。肝静态显像和肝血流动力学检查结果表明:(1)~(99m)Tc-NGA显像可提供良好的肝脏影像,(2)肝血流动力学检查是诊断肝疾病的新手段。
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| 关 键 词： | 放射性核素显像 受体 配位体 肝细胞瘤 |
The Preparation of ~99mTc-NGA for Hepatocellular Receptor Imaging and Its Predinical Study in Rabbits |
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| Kong Lingshan,Xu Dengren,Pan Wenzhou,Chu Jianxiong,Li Hongxun.The Preparation of ~99mTc-NGA for Hepatocellular Receptor Imaging and Its Predinical Study in Rabbits[J].Academic Journal of Second Military Medical University,1992(1). |
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| Authors: | Kong Lingshan Xu Dengren Pan Wenzhou Chu Jianxiong Li Hongxun |
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| Abstract: | Technetium-99m galactosyl-neoglycoalbumin (99mTc-NGA) is a new hepatocellular receptor imaging ligand Its preparation and preclinical research are reported in this paper. The ligand was synthesized by the chemical coupling and the product was nontoxic and apyrogenic with good stability both in vivo and in vitro. The static images and kinetic data obtained from the liver portal vein ligation group (n = 2), the hepatic necrosis group (n=2) and the control group (n=6) indicate: (1) Tc-NGA imaging can provide excellent hepatic images, and (2) hepatic kinetic data appear to provide a new means for diagnosis of liver diseases. |
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| Keywords: | radionuclide imaging receptors ligands hepatoma |
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