| 盐酸吡格列酮的合成 |
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| 引用本文： | 楼晨光,高丽梅,宋丹青.盐酸吡格列酮的合成[J].中国新药杂志,2005,14(10):1187-1189. |
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| 作者姓名： | 楼晨光 高丽梅 宋丹青 |
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| 作者单位： | 中国医学科学院中国协和医科大学医药生物技术研究所,北京,100050 |
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| 摘 要： | 目的:合成盐酸吡格列酮.方法:以2-(5-乙基-2-吡啶基)乙醇(5-EPE)为起始原料,经缩合、还原、重氮化、环化、水解及成盐等6步反应得到盐酸吡格列酮.结果:目标化合物经质谱、核磁共振氢谱、红外光谱及X-单晶衍射等确证其化学结构,总收率为12.8%.结论:本路线可简化实验操作,降低成本,适合工业化生产.
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| 关 键 词： | 盐酸吡格列酮 药物合成 糖尿病 |
| 文章编号： | 1003-3734（2005）10-1187-03 |
| 收稿时间： | 2005-03-24 |
| 修稿时间： | 2005-03-24 |
Synthesis of pioglitazone hydrochloride |
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| LOU Chen-guang,GAO Li-mei,SONG Dan-qing.Synthesis of pioglitazone hydrochloride[J].Chinese Journal of New Drugs,2005,14(10):1187-1189. |
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| Authors: | LOU Chen-guang GAO Li-mei SONG Dan-qing |
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| Institution: | Institute of Medicinal Biotechnology, China Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Objective:To synthesize pioglitazone hydrochloride.Methods: The target compound was synthesized from 2-(5-ethyl-2-pyridyl)-ethanol as a starting material via six steps including condensation,reduction,diazotization,cyclization,hydrolysis and saltilization.Results: The structure of the target compound was confirmed by MS,()~1H-NMR,IR and X-ray crystal analysis.The total yield of pioglitazone hydrochloride was 12.8%.Conclusion: This cost-saving and simplified method can be used in the industrial manufacture. |
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| Keywords: | pioglitazone hydrochloride synthesis diabetic disease |
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