| 1-(3-氟苯基)-5-甲基-2-(1H)吡啶酮对鼠肾成纤维细胞的影响 |
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| 引用本文： | 陶立坚,张军,胡高云,陈卓,龚娟. 1-(3-氟苯基)-5-甲基-2-(1H)吡啶酮对鼠肾成纤维细胞的影响[J]. 中南大学学报(医学版), 2004, 29(2): 139-141 |
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| 作者姓名： | 陶立坚 张军 胡高云 陈卓 龚娟 |
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| 作者单位： | 中南大学,湘雅医院肾内科,长沙,410008;中南大学,药学院药物化学系,长沙,410008 |
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| 摘 要： | 目的：探讨1- (3-氟苯基)-5-甲基-2-（1H）吡啶酮对鼠肾纤维化的治疗作用。 方法：采用MTT法和ELISA法分别检测1-(3-氟苯基)-5-甲基-2-（1H）吡啶酮和pirfenidone对鼠肾成纤维细胞（BHK-21）增殖和分泌纤维结合蛋白（Fn）表达的影响。 结果：1-(3-氟苯基)-5-甲基-2-（1H）吡啶酮作用于鼠肾成纤维细胞48 h后能明显抑制细胞增殖及分泌Fn，1 000 μg/ml的1-(3-氟苯基)-5-甲基-2-（1H）吡啶酮作用于BHK-21后24 h即可明显抑制BHK-21细胞增殖。 结论：1-(3-氟苯基)-5-甲基-2-（1H）吡啶酮可明显抑制鼠肾成纤维细胞增殖，在肾间质纤维化防治药物研制方面显示出良好的前景。
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| 关 键 词： | 1-(3-氟苯基)-5-甲基-2-(1H)吡啶酮 肾间质纤维化 成纤维细胞 纤维结合蛋白 |
| 文章编号： | 1672-7347(2004)02-0139-03 |
| 收稿时间： | 2004-01-01 |
| 修稿时间： | 2004-01-01 |
Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridoneon renal fibroblast in rats |
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| TAO Li jian ,,ZHANG Jun ,HU Gao yun ,et al.. Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridoneon renal fibroblast in rats[J]. Journal of Central South University. Medical sciences, 2004, 29(2): 139-141 |
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| Authors: | TAO Li jian ZHANG Jun HU Gao yun et al. |
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| Affiliation: | 1.Department of Nephrology, Xiangya Hospital；2.Department of Medical Chemistry，School of Pharmaceutical Science，Central South University, Changsha 410008，China |
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| Abstract: | OBJECTIVE: To explore the curative effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone (FMP) on renal fibrosis in rats. METHODS: The effects of FMP on the cell proliferation and Fn secretion were measured by methyl thiazolyl tetrazolium and enzyme-linked immunoabsorbent assay, respectively. RESULTS: FMP obviously inhibited the proliferation and Fn secretion in rat renal fibroblast 48 hours after the treatment. FMP (1 000 microg/ml) obviously inhibited the proliferation of rat renal fibroblast 24 hours after the treatment. CONCLUSION: 1-(3-Fluorophenyl) -5-methyl-2-(1H)-pyridone can obviously inhibit the proliferation of rat renal fibroblast, which may be effective for renal interstitial fibrosis prevention and treatment. |
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| Keywords: | fluorophenyl) 5 methyl 2 (1H) pyridone renal interstitial fibrosis fibroblast fibronectin |
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