| 刺老苞根皮黄酮类化合物对抗大鼠泼尼松性骨质疏松的作用研究 |
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| 引用本文： | 裴凌鹏,郑玲玲,尹霞,刘伟志. 刺老苞根皮黄酮类化合物对抗大鼠泼尼松性骨质疏松的作用研究[J]. 时珍国医国药, 2011, 22(7). DOI: 10.3969/j.issn.1008-0805.2011.07.005 |
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| 作者姓名： | 裴凌鹏 郑玲玲 尹霞 刘伟志 |
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| 作者单位： | 1. 中央民族大学,教育部中国少数民族传统医学重点实验室,北京,100081
2. 中国中医科学院,望京医院,骨伤科研究所,北京,100070 |
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| 基金项目： | 国家自然科学基金，教育部长江学者与创新团队计划项目 |
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| 摘 要： | 目的 研究刺老苞根皮黄酮类化合物对泼尼松致大鼠骨质疏松的对抗作用.方法 将50只大鼠随机分成正常对照组、泼尼松模型组和刺老苞根皮黄酮类化合物高、中、低(10,20,30 mg/kg)剂量组,每组10只.分别灌胃相应药物,1次/d,连续8周后取血清检测生化指标,对骨进行组织切片检查,长度、宽度以及骨质的测量.结果 泼尼松模型组大鼠股骨重量、尺骨骨羟脯氨酸和骨钙含量比正常对照组明显降低,胫骨骨髓腔中脂肪组织增多(P<0.01),血浆胆固醇(TG)含量上升、碱性磷酸酶(ALP)和高密度脂蛋白(HDL)含量下降(P<0.01).刺老苞根皮黄酮类化合物组能有效提高骨的重量和骨质的含量(P<0.01),减少骨髓腔中脂肪的含量,升高碱性磷酸酶和高密度脂蛋白含量(P<0.01).结论 泼尼松可抑制大鼠的骨生长及引起骨丢失,而刺老苞根皮黄酮类化合物可有良好的对抗作用.
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| 关 键 词： | 刺老苞根皮 黄酮类化合物 泼尼松 骨质疏松 |
Effect of Aralia echinocaulis Hand.Mazz Flavonoids on Osteoporosis Induced by Predni-sone in Rats |
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| PEI Ling-peng,ZHENG Ling-ling,YIN Xia,LIU Wei-zhi. Effect of Aralia echinocaulis Hand.Mazz Flavonoids on Osteoporosis Induced by Predni-sone in Rats[J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(7). DOI: 10.3969/j.issn.1008-0805.2011.07.005 |
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| Authors: | PEI Ling-peng ZHENG Ling-ling YIN Xia LIU Wei-zhi |
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| Affiliation: | PEI Ling-peng1,ZHENG Ling-ling1,YIN Xia2,LIU Wei-zhi1(1.University of China,Key Lab of Minority Traditional Medicine,National Ministry of Education,Beijing 100081,China,2.Wangjing Hospital,Academy of TCM Science of China,Beijing 100070,China) |
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| Abstract: | ObjectiveTo investigate the effect of Aralia echinocauIis Hand.Mazz flavonoids on osteoporosis induced by prednisone in rats.MethodsFifty SD rats were randomly divided into control group,prednisone group,Aralia echinocauIis Hand.Mazz flavonoids low dosage group(10 mg/kg),middle dosage group(20 mg/kg) and high dosage group(30 mg/kg).Rats in control group were treated with dissolvent,the others were treated with prednisone firstly,and then,the rats in prednisone group were treated with dissolvent,the rats in ... |
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| Keywords: | Aralia echinocauIis Hand.Mazz Flavonoids Prednisone Osteoporosis |
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