疏血通注射液联合卡托普利对老年高血压患者血压昼夜节律及血浆内皮素和一氧化氮的影响

目的 探讨疏血通注射液联合卡托普利对老年高血压患者血压昼夜节律及血浆内皮素、一氧化氮含量的影响.方法 将老年高血压病患者随机分为治疗组40例和对照组36例.治疗组采用疏血通注射液联合卡托普利治疗,对照组单用卡托普利治疗,疗程均为14天.治疗1疗程后观察并比较两组患者血压昼夜节律及血浆内皮素、一氧化氮水平的变化.结果 治疗组降压疗效优于对照组(P＜0.01),中西药联用在改善老年高血压患者昼夜节律变化方面优于对照组,且治疗组中的血浆内皮素、一氧化氮水平变化与对照组比较差异有显著性(P＜0.05).结论 疏血通注射液联合卡托普利能有效改善老年高血压患者血压昼夜节律变化.提高一氧化氮水平,降低血浆内皮素含量,具有较好的降压效果,值得在临床推广.

The Effect of Shuxuetong Injection Combined with Captopril on Circadian Rhythm of Blood Pressure and Plasma Endothelin and Nitric Oxide in Elderly Hypertension

Aim To explore the effect of Shuxuetong injection combined with captopril on elderly hypertension patients'' plasma endothelin(ET) and nitric oxide(NO) contents. Methods Elderly patients with hypertension were randomly divided into treatment group(n=40) and control group(n=36).Treatment group was treated with Shuxuetong injection and captopril,while control group was only given captopril,with 14d as a period course.The change of circadian rhythm of blood pressure,plasma ET and NO after treated for one course was observed. Results The treatment group was better than control group in antihypertensive effects(P<0.01).The improvement of rhythm diurnal variation by traditional and western medicine was better than control group in elderly hypertension.Compared with control group,treatment group''s change of plasma ET and NO level had significant difference(P<0.05). Conclusions The combination of Shuxuetong injection and captopril can effectively improve elderly patients'' circadian rhythm of blood pressure,increase the NO contents and decrease plasma ET.It has a better effect of longtime hypotensive,and it is worth in clinical widely.