冠心病患者血清可溶性低密度脂蛋白受体、髓系相关蛋白8/14复合物及嗜酸性粒细胞阳离子蛋白水平变化及临床意义

目的 观察冠心病患者血清可溶性低密度脂蛋白受体(sLR11)、髓系相关蛋白8/14复合物(MRP8/14)及嗜酸性粒细胞阳离子蛋白(ECP)水平的变化,探讨其与冠状动脉病变程度及斑块稳定性的关系.方法 采用酶联免疫吸附法检测71例急性冠状动脉综合征患者、51例稳定型心绞痛患者及53例健康对照者血清sLR11、MRP8/14及ECP的水平.所有入组者均行冠状动脉造影,计数冠状动脉病变Gensini积分及冠状动脉病变支数,并与血清sLR11、MRP8/14及ECP水平进行相关分析.结果 急性冠状动脉综合征组、稳定型心绞痛组sLR11、MRP8/14及ECP水平显著高于对照组(P<0.01);急性冠状动脉综合征组sLR11(30.50±10.48 ng/L比22.13±6.33 ng/L)、MRP8/14水平(40.30±12.59 ng/L比29.12±10.27 ng/L)明显高于稳定型心绞痛组(均P<0.05),ECP水平略高于稳定型心绞痛组,但差异无显著性(29.47±7.16 μg/L比23.73±5.67 μg/L,P>0.05).冠状动脉3支病变组血清sLR11、ECP水平明显高于2支病变组和单支病变组(均P<0.05),而2支病变组与单支病变组差异无显著性(P>0.05).sLR11、ECP水平与冠状动脉病变Gensini积分呈正相关,而MRP8/14水平与冠状动脉病变支数、冠状动脉病变Gensini积分无显著相关(P>0.05).结论 冠心病患者血清sLR11、ECP水平与冠状动脉病变支数及狭窄程度相关,ECP与斑块的生长稳定有关,MRP8/14水平的提高可能提示动脉粥样硬化斑块的不稳定性,可预测急性冠状动脉事件的发生.冠心病患者sLR11、MRP8/14及ECP水平明显升高,对判断冠心病的类型及病情演变有重要意义,有望成为冠心病患者新的生物标志物.

Clinical Significance of Circulating Levels of Soluble Low-Density Lipoprotein Receptor,Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein of Atherosclerosis

Aim To investigate the levels of soluble low density lipoprotein receptor(sLR11),myeloid-related protein-8/14(MRP8/14) and eosinophil cationic protein(ECP) in coronary heart disease and their relationships with coronary artery disease. Methods The levels of serum sLR11,MRP8/14 and ECP were measured by enzyme-linked immunosorbent assay in 71 patients with acute coronary syndrome(ACS),51 patients with stable angina pectoris(SAP),and 53 controls.All subjects were underwent coronary angiography.The numbers of i...