| 慢性前列腺炎模型大鼠脊髓背角降钙素基因相关肽表达的测定 |
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| 引用本文： | 陈瑾歆,李云祥,王安果,张宗平. 慢性前列腺炎模型大鼠脊髓背角降钙素基因相关肽表达的测定[J]. 中国疼痛医学杂志, 2011, 17(8). DOI: 10.3969/j.issn.1006-9852.2011.08.015 |
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| 作者姓名： | 陈瑾歆 李云祥 王安果 张宗平 |
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| 作者单位： | 1. 川北医学院生物化学教研室
2. 南充市中心医院泌尿外科,南充.,637000 |
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| 基金项目： | 四川省卫生厅研究项目(080227)资助课题，2009南充市科技局资助课题 |
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| 摘 要： | 目的:检测慢性前列腺炎模型大鼠脊髓背角降钙素基因相关肽(Calcitonin Gene-Related Peptide,CGRP)的表达.方法:雄性SD大鼠16只,随机分为正常对照组和实验组,实验组在大鼠前列腺侧叶注射完全弗氏佐剂制备慢性前列腺炎模型,Taqman荧光PCR相对定量法检测各组大鼠脊髓背角中CGRP的表达.结果:慢性前列腺炎模型大鼠脊髓背角中CGRP mRNA的表达水平为1.12±0.01,比正常对照组明显增加(P<0.01).结论:CGRP在慢性前列腺炎模型大鼠脊髓背角中表达显著增加,可能参与慢性前列腺炎疼痛的形成.
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| 关 键 词： | 慢性前列腺炎 脊髓背角 降钙素基因相关肽 |
EXPRESSION OF CALCITONIN GENE-RELATED PEPTIDE IN CORNU DORSALE MEDULV SPINALIS OF RATS MODEL WITH CHRONIC PROSTATITIS |
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| CHEN Jin-Xin,LI YunXiang,WANG An-Guo,ZHANG ZongPing. EXPRESSION OF CALCITONIN GENE-RELATED PEPTIDE IN CORNU DORSALE MEDULV SPINALIS OF RATS MODEL WITH CHRONIC PROSTATITIS[J]. Chinese Journal of Pain Medicine, 2011, 17(8). DOI: 10.3969/j.issn.1006-9852.2011.08.015 |
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| Authors: | CHEN Jin-Xin LI YunXiang WANG An-Guo ZHANG ZongPing |
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| Affiliation: | CHEN Jin-Xin1,LI Yun-Xiang2,WANG An-Guo2,ZHANG Zong-Ping2(1Department of Biochemistry,North Sichuan Medical College,2Department of Urology,Nanchong Central Hospital,Nanchong 637000) |
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| Abstract: | Objective: To detect the expression of CGRP in cornu dorsale medullais spinalis of rats model with CP.Methods:16 SD male-rats were randomly divided into two groups:normal control and CP experiment group which was induced by lateral lobe of prostate gland injection of complete Freund's adjuvant.The expression levels of CGRP and GAPDH were measured by relative quantification Taqman real-time PCR in rats model with CP.Results:The expression of CGRP in cornu dorsale medullae spinalis of rats model with CP is 1.... |
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| Keywords: | Chronic prostatitis Cornu dorsale medullae spinalis CGRP |
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