| 唐古特瑞香抗炎镇痛活性部位筛选研究 |
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| 引用本文： | 李赛雷,邵峰,刘荣华,任刚,黄慧莲,陈石生,史晓伟.唐古特瑞香抗炎镇痛活性部位筛选研究[J].时珍国医国药,2011,22(7):1586-1587. |
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| 作者姓名： | 李赛雷 邵峰 刘荣华 任刚 黄慧莲 陈石生 史晓伟 |
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| 作者单位： | 江西中医学院现代中药制剂教育部重点实验室,江西,南昌,330004 |
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| 基金项目： | 江西省自然科学基金，浙江省优秀青年人才研究计划 |
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| 摘 要： | 目的筛选出唐古特瑞香抗炎镇痛的活性部位。方法采用醋酸扭体法、小鼠腹腔毛细血管通透性试验以及二甲苯致小鼠耳肿胀试验,分别以小鼠扭体反应次数、毛细管通透性、小鼠耳肿胀度以及胀抑制率为考察指标,对唐古特瑞香的乙醚部位、50%乙醇部位、30%乙醇部位、水部位进行抗炎镇痛药效筛选。结果唐古特瑞香乙醚部位(0.44 g/kg)可明显减少冰醋酸所致的小鼠扭体次数(P<0.01)及冰醋酸所致小鼠毛细血管通透性增加(P<0.01)和抑制二甲苯所致小鼠耳肿胀(P<0.05)。结论唐古特瑞香乙醚部位为抗炎镇痛的药效部位,为唐古特瑞香开发研究提供科学依据。
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| 关 键 词： | 唐古特瑞香 抗炎 镇痛 |
Screening of Anti-inflammatory and Analgesic Parts of Daphne tangutica Maxim |
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| LI Sai-lei,SHAO Feng,LIU Rong-hua,REN Gang,HUANG Hui-lian,CHEN Shi-sheng,SHI Xiao-wei.Screening of Anti-inflammatory and Analgesic Parts of Daphne tangutica Maxim[J].Lishizhen Medicine and Materia Medica Research,2011,22(7):1586-1587. |
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| Authors: | LI Sai-lei SHAO Feng LIU Rong-hua REN Gang HUANG Hui-lian CHEN Shi-sheng SHI Xiao-wei |
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| Institution: | LI Sai-lei,SHAO Feng,LIU Rong-hua,REN Gang,HUANG Hui-lian,CHEN Shi-sheng,SHI Xiao-wei(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China) |
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| Abstract: | ObjectiveTo screen out the active parts of Daphne tangutica Maxim through anti-inflammatory and analgesic experiments.MethodsThe times of the acetic acid-induced writhing test in mice,the inhibition percentage of xylene-induced ear edema and acetic acid-induced capillary permeability in abdominal cavity in mice were used to screen the active parts from the diethyl ether extract,50% ethanol extract,30% ethanol extract,water extract of Daphne tangutica Maxim.ResultsThe diethyl ether extract of Daphne tangutic... |
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| Keywords: | Daphne tangutica Maxim Anti-inflammation Analgesia |
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