| Alzheimer病中枢肾上腺素能系统的变化 |
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| 引用本文： | 王跃春,王子栋,何斯纯,郑辉,周丽丽.Alzheimer病中枢肾上腺素能系统的变化[J].中国病理生理杂志,2002,18(9):1162-1164. |
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| 作者姓名： | 王跃春 王子栋 何斯纯 郑辉 周丽丽 |
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| 作者单位： | 暨南大学医学院生理学教研室,广东,广州,510632 |
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| 基金项目： | 广东省卫生系统“五个一科教兴医工程”(No .0 4 345 )，国务院侨办重点课题科研基金资助项目 (No .9395 0 6 ) |
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| 摘 要： | 关于阿尔兹海默病 (Ａｌｚｈｅｉｍｅｒ’ｓｄｉｓｅａｓｅ ,ＡＤ)中枢去甲肾上腺素 (ｎｏｒａｄｒｅｎａｌｉｎ ,ＮＥ)能系统的异常 ,各种报道不尽一致 ,基本上有降低和升高两种情况。蓝斑核ＮＥ能神经元的显著丧失导致脑脊液和皮层及皮层下区域ＮＥ浓度下降 ,这易于理解 ;但有些ＡＤ脑脊液中ＮＥ浓度不变甚至升高 ,这种在体发现似乎与尸检蓝斑核神经元丢失不一致 ,本文着重对此展开综述 ,并对目前临床上与ＮＥ相关的ＡＤ的药物治疗进行归纳和分析。1 ＡＤ患者中枢ＮＥ的变化1 1 ＡＤ患者中枢ＮＥ水平下降 早在 1987年Ｂｏｎ ｄａｒｅｆ…
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| 关 键 词： | 去甲肾上腺素 阿尔茨海默病 药物疗法 |
| 文章编号： | 1000-4718(2002)09-1162-03 |
| 收稿时间： | 2001-05-11 |
| 修稿时间： | 2001年5月11日 |
Change of central noradrenergic system in Alzheimer's disease |
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| WANG Yao-chun,WANG Zi-dong,HE Si-chun,ZHENG Hui,ZHOU Li-li.Change of central noradrenergic system in Alzheimer''''s disease[J].Chinese Journal of Pathophysiology,2002,18(9):1162-1164. |
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| Authors: | WANG Yao-chun WANG Zi-dong HE Si-chun ZHENG Hui ZHOU Li-li |
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| Institution: | Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China |
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| Abstract: | The abnormality of the central noradrenergic system in Alzheimer's disease has two cases: decrease or increase. The former is easy to be understood, because it is resulted from the outstanding forfeit of the noradrenergic neurons in the nucleus locus ceruleus (nLC); but the noradrenalin concentration does not change and enen increase, it seems to disagree with the loss of the noradrenergic neurons in the nLC. This article put emphasis on it, enumerated the related evidence and analyzed the possible causes. At present time, the drugs to increase noradrenalin is used mostly in clinic. This paper summarized it and put forth our own opinions. |
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| Keywords: | Norepinephrine Alzheimer's disease Drugtherapy |
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