A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N) |
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| Authors: | F. Poli P. Bianchi M. Scalamogna L. Crespiatico N. Ghidoli G. Puglisi G. Sirchia |
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| Affiliation: | Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milan, Italy. nitpmi@polic.cilea.it |
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| Abstract: | We report herein the identification of a new HLA-A null allele. This allele, A*0105N, was detected during histocompatibility testing of a cord blood donor and the respective mother. Serologic typing results contrasted those obtained with DNA typing that alone showed the presence of HLA-A*01. ThisA*0105N was due to a nucleotide deletion in exon 4 that altered the reading frame, causing a premature termination. |
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| Keywords: | HLA-A null allele MHC |
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