Epigenomic mapping in <Emphasis Type="Italic">Arabidopsis</Emphasis> using tiling microarrays |
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Authors: | Email author" target="_blank">Robert?A?MartienssenEmail author R?W?Doerge Vincent?Colot |
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Institution: | (1) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA;(2) Department of Statistics, Purdue University, West Lafayette, IN 47907, USA;(3) Unité de Recherche en Génomique Végétale (URGV), INRA/CNRS/UEVE, 2 Rue Gaston Crémieux, 91057 Evry Cedex, France |
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Abstract: | In addition to genetic information, chromosomes transmit epigenetic information from cell to cell during division, and sometimes
from generation to generation. While genetic information is encoded directly in the DNA sequence, epigenetic information is
not, although it is usually associated with specific chromosomal regions. Epigenetic modifications in plants include cytosine
methylation as well as modification of histones and other chromosomal proteins. Small interfering RNA play major roles in
targeting these modifications to specific regions. Genomic tiling microarrays are powerful tools for analysing epigenetic
information, and we review their application in building epigenomic maps in the model plant, Arabidopsis. |
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Keywords: | Arabidopsis epigenetics heterochromatin histone methylation tiling microarrays |
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