辛伐他汀对稳定性冠心病患者的血清高敏C-反应蛋白水平的影响

目的探讨辛伐他汀20mg/d对稳定性冠心病患者降脂达标率及血清高敏C-反应蛋白(hs-CRP)水平的影响。方法34例稳定性冠心病患者(其中男26例,女8例),年龄41～79岁,平均(64.4±11.3)岁,服用辛伐他汀20mg/d,疗程12周。治疗前、治疗4周及12周时分别检测血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、肌酐(Cr)、尿素氮(BUN)、尿酸(UA)、血糖(GLU)、肌酸激酶(CPK)及血清高敏C-反应蛋白(hs-CRP)。结果辛伐他汀20mg/d治疗12周降低TC、LDL-C、TG的幅度分别为34.8%、46.1%、24.7%;升高HDL-C2.0%,使76.5%冠心病患者LDL-C降至目标值,并可显著降低hs-CRP水平(P=0.018)。结论辛伐他汀20mg/d治疗冠心病患者有较高的降脂达标率,并可能有利于抑制炎症反应。

Effect of Simvastatin on High Sensitivity C-reactive Protein in Serum of Patients with Stable Coronary Artery Disease

Objective To explore the effect of simvastatin on high sensitivity C-reactive protein in serum of patients with stable coronary artery disease.Methods 34 patients with stable coronary artery disease at the age of 41～79 years old(26 males and 8 females,mean age at 64.4±11.3 years old) were given 20 mg/d simvastatin at night.The therapeutic course was 12 weeks.Fasting serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),high sensitivity C-reactive protein(hs-CRP) and other biochemistry data were examined before and after 4 and 12 weeks' treatment.Results After 12 weeks' treatment,TC,LDL-C,TG significantly decreased by 34.8%,46.1% and 24.7%,but HDL-C increased by 2.0% slightly.76.5% patients could reach Chinese standard level of LDL-C,and the Hs-CRP level decreased significantly(P=0.018).Conclusion The use of 20 mg/d simvastatin is efficacious at lowering LDL-C levels and allowing patients to achieve their goal to low cholesterol level,and may be beneficial to inhibiting inflammatory response in patients with stable coronary artery disease.