Azadirachtin derivatives from seed kernels of Azadirachta excelsa |
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Authors: | Kanokmedhakul Somdej Kanokmedhakul Kwanjai Prajuabsuk Thirada Panichajakul Sanha Panyamee Piyanan Prabpai Samran Kongsaeree Palangpon |
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Institution: | Department of Chemistry, Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. somdej@kku.ac.th |
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Abstract: | Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11alpha-azadirachtin H (7), 11beta-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were established by spectroscopic techniques, and the structure of 3 was confirmed by X-ray analysis. Compounds 1-7 and 9 exhibited toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 0.75-1.92 microg/g body weight, in 92 h. |
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