巨噬细胞移动抑制因子、高敏C-反应蛋白与颈动脉粥样硬化和急性脑梗死的关系

目的探讨巨噬细胞移动抑制因子、高敏C-反应蛋白与颈动脉粥样硬化和急性脑梗死的关系。方法103例首次发病的脑梗死患者和40例健康体检者,应用酶联免疫双抗体夹心法测定血清MIF浓度,免疫散射比浊法测定血清hs-CRP浓度。应用颈动脉超声检测颈动脉内膜状况,并对急性脑梗死患者进行神经功能缺损评分。结果急性脑梗死患者血清MIF和hs-CRP浓度显著高于正常对照组(P<0.01)。不稳定斑块组(混合斑块组、软斑组)血清MIF和hs-CRP浓度显著高于稳定斑块组(硬化斑块组)和内膜粗糙组(P<0.01)。血清MIF和hs-CRP浓度分别与急性脑梗死患者神经功能缺损评分呈正相关。结论急性脑梗死患者血清MIF和hs-CRP水平可以反映颈动脉斑块的性质和稳定性,是临床了解脑梗死严重程度的重要指标。

Role of Macrophage Migration Inhibition Factor and High-Sensitive C-Reactive Protein in Carotid Atherosclerosis and Acute Cerebral Infarction

Objective To investigate the relationship between the levels of macrophage migration inhibition factor(MIF) and high-sensitive C-reactive protein (hs-CRP),and the incidence of carotid atherosclerosis and acute cerebral infarction. Method One hundred and three patients with first-ever cerebral infarction and 40 normal control subjects were studied. The levels of serum MIF were determined by double antibody enzyme-linked immunosorbent assay,and the levels of serum hs-CRP were measured by immunonephelometric assay. The thickness of carotid intima-media was assessed by carotid ultrasonography.Neurological deficit scores were determined in patients with acute cerebral infarction. Result The levels of serum MIF and hs-CRP in patients with acute cerebral infarction were significantly higher than the normal control subjects (P <0.01).The levels of serum MIF and hs-CRP in unstable plaque groups (mixed and soft plaque group) were significantly higher than those in stable plaque group (hard plaque group) and rough intima group (P<0.01). The levels of serum MIF and hs-CRP were positively correlated with the neurological deficit scores in patients with acute cerebral infartion. Conclusion The levels of serum MIF and hs-CRP in patients with acute cerebral infarction may reflect the features and stability of carotid artery plague. It may be used as an index to indicate the severity of cerebral infarction in clinical practice.