肝脏缺血预处理在肝癌围手术期中的作用

目的 观察缺血预处理(ischemic preconditioning,IP)在肝癌围手术期的作用.方法 IP组35例,对照组25例,IP组肝切除前采用10min/10 min的缺血预处理,肝门阻断方法(Pringle手法)、肝切除方法与步骤与对照组类似,比较两组术前、术后肝酶的变化、术中出血与输血量、术后并发症、住院天数、住院费用的区别.结果 两组术中肝门阻断时间、出血量、输血量无明显区别(P>0.05).术后两组肝酶均有明显升高,但IP组谷丙转氨酶在术后1 d、3 d、7 d的升高值明显低于对照组(P<0.025),IP组术后肝功能不全的发生率、住院天数和住院费用明显较对照组低(P<0.05).结论 肝癌手术时采用缺血预处理为一简单有效的保护肝功能的方法.

Effect of ischemic preconditioning on hepatic cancer in perioperation

Objective To observe the protective effect of ischemic preconditioning(IP) in the perioperation of liver cancer.Methods IP group had 35 patients and the control group had 25.IP group patients received a 10 min ischemia followed by 10 min perfusion before hepatectomy.The serum concentration of ALT was measured before operation and 1 day,three days and seven days after operation respectively.The intraoperative blood loss,postoperative complications,mortality,hospitalized duration and the cost were also examin...