生长激素不同应用时间对IVF助孕结局的影响

目的通过分析重组生长激素(rGH)不同应用时间对多周期体外受精(IVF)患者助孕结局的影响,探讨rGH应用于多周期IVF患者的最佳时间。方法选择西北妇女儿童医院生殖中心2017年1月至2018年6月多周期行IVF助孕且采用rGH辅助治疗的198例患者,其中一部分患者采用长期辅助治疗即促排卵前1月开始用rGH直至HCG日,为长期治疗组(109例);另一部分患者采用短期辅助治疗即促排卵同步应用rGH至HCG日,为短期治疗组(89例)。比较两组患者正常受精率、优胚率、临床妊娠率、早期流产率等的差异。结果两组患者间年龄、不孕年限、基础窦卵泡数(AFC)、基础FSH及BMI比较均无显著性差异(P>0.05);促排卵过程中两组患者的Gn用量及Gn天数亦均无显著性差异(P>0.05);长期治疗组和短期治疗组的内膜厚度[(11.80±2.59)mm vs.(10.94±2.40)mm]、获卵数[(10.28±5.59)vs.(8.35±4.88)]、HCG日E2水平[(13 963.90±10 209.89)pmol/L vs.(10 893.43±8 240.21)pmol/L]及HCG...

Effect of application time of growth hormone on IVF pregnancy outcome

Objective:To explore the optimal time for using recombinant growth hormone(rGH)by analyzing the effect of different application time of rGH on the pregnancy outcome in the patients with multiple cycles of IVF treatment.Methods:The data of 198 patients who underwent multiple cycles of IVF and received rGH as adjuvant therapy in the reproductive center of Northwest Women and Children’s Hospital from January 2017 to June 2018 were retrospectively analyzed.The patients received rGH adjuvant therapy one month before ovulation induction to HCG day as a long-term treatment group(n=109),and other patients were simultaneously applied rGH while inducing ovulation to HCG day as short-term treatment group(n=89).The differences of normal fertilization rate,high quality embryo rate,clinical pregnancy rate and early abortion rate were compared between the two groups.Results:There were no significantly difference in age,infertility duration,basal antral follicle count(AFC),basal FSH levels and BMI between two groups(P>0.05).The dosage and days of Gn used were also no significantly different(P>0.05).Endometrial thickness on HCG day[(11.80±2.59)mm vs.(10.94±2.40)mm],the number of oocytes retrieved[(10.28±5.59)vs.(8.35±4.88)],E 2 level on HCG day[(13963.90±10209.89)pmol/L vs.(10893.43±8240.21)pmol/L]and progesterone level on HCG day[(4.42±2.13)nmol/L vs.(3.66±2.13)nmol/L]were significantly different between the long-term treatment group and short-term treatment group(P>0.05).There was no significantly difference in normal fertilization rate and early abortion rate between two groups(P>0.05).The high quality embryo rate(30.77%vs.31.42%)and pregnancy rate(46.15%vs.54.55%)in long-term treatment group were slightly lower than those in short-term treatment group(P>0.05).Conclusions:Long-term adjuvant therapy with rGH can increase the number of oocytes retrieved and the thickness of endometrium.However,there was no significant improvement in normal fertilization rate,high quality embryo rate and clinical pregnancy rate.After long-term GH adjuvant therapy,the pregnancy rate has a downward trend,whether the cause is related to the increase in progesterone needs further research and exploration.