| 糖尿病肾病足细胞损伤的表观遗传调控 |
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| 作者单位： | 山东中医药大学第一临床医学院;山东中医药大学附属医院肾病科 |
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| 基金项目： | 国家自然科学基金面上项目(81673812);国家自然科学基金面上项目(81874440);山东省医药卫生科技发展计划项目(2018WS188);山东省重点研发计划项目(2018GSF119017);济南市科技计划项目(201907107)。 |
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| 摘 要： | 表观遗传修饰是糖尿病肾病的重要机制之一,足细胞损伤是疾病进展的核心事件。不同表观遗传修饰方式可通过单独作用或交叉对话,改变足细胞结构和功能、促进足细胞凋亡及上皮间充质转化、影响足细胞自噬,以及参与足细胞内质网应激和线粒体功能障碍等过程,参与足细胞损伤。表观遗传是可逆的,通过治疗干预改变表观遗传修饰可能是防治糖尿病肾病的一个重要方向。
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| 关 键 词： | 表观遗传修饰 足细胞 糖尿病肾病 |
Epigenetic regulation of podocyte injury in diabetic nephropathy |
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| Institution: | (First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250011,China;Department of Nephrology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China) |
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| Abstract: | Epigenetic modification is one of the important mechanisms of diabetic nephropathy,and podocyte injury is the core event.Epigenetic modification can affect podocytes by altering podocyte structure and function,promoting podocyte apoptosis and epithelial mesenchymal transition,affecting podocyte autophagy,and participating in podocyte endoplasmic reticulum stress and mitochondrial dysfunction.Different epigenetic modifications participate in podocyte injury through cross-talk and interaction.Epigenetics is reversible,changing epigenetic modification through therapeutic intervention may be an important direction for prevention and treatment of diabetic nephropathy. |
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| Keywords: | epigenetic modification podocyte diabetic nephropathy |
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