食管癌患者癌组织COX-2、VEGF-C表达水平对其预后生存的影响

目的分析食管癌患者癌组织环氧合酶2(COX-2)、血管内皮生长因子C(VEGF-C)表达水平对其预后生存的影响。方法回顾性分析2015年4月到2016年10月池州市人民医院经病理确诊的60例食管癌患者临床资料,采用免疫组织化学染色法检测其癌组织标本、癌旁正常食管黏膜组织标本中COX-2、VEGF-C蛋白表达水平,分析癌组织COX-2、VEGF-C表达水平的相关性,分析COX-2、VEGF-C表达水平与患者临床病理特征、预后生存的关系。结果食管癌组织标本中COX-2、VEGF-C表达阳性率均高于癌旁正常食管黏膜组织标本,差异有统计学意义(P<0.05);Spearman相关分析显示,食管癌患者癌组织COX-2表达阳性率与VEGF-C表达阳性率呈正相关(r=0.388,P<0.05);食管癌患者COX-2表达水平与性别、年龄、病理类型无关(P>0.05),而与分化程度、TNM分期、淋巴结转移有关(P<0.05),VEGF-C表达水平与性别、年龄、病理类型、TNM分期无关(P>0.05),而与分化程度、淋巴结转移有关(P<0.05);COX-2阳性患者12个月生存率低于COX-2阴性患者,VEGF-C阳性患者12个月生存率低于VEGF-C阴性患者,但差异无统计学意义(P>0.05);不同COX-2、VEGF-C表达水平患者12个月复发率比较,差异无统计学意义(P>0.05)。结论食管癌患者癌组织中COX-2、VEGF-C表达水平高,且其与临床病理参数也有一定关联,对预后生存的影响尚不明显,但临床检测COX-2、VEGF-C仍可为食管癌患者的预后评估提供参考。

Effect of COX-2 and VEGF-C expression in cancer tissue on prognosis of esophageal cancer patients

Objective To analyze the expression of cyclooxygenase 2(COX-2)and vascular endothelial growth factor C(VEGF-C in cancer tissue of esophageal cancer patients and their effect on prognosis.Methods The clinical data of 60 patients who were pathologically confirmed with esophageal cancer in our hospital from April 2015 to October 2016 were retrospectively analyzed.The expression levels of COX-2 and VEGF-C in cancer tissue and in adjacent normal esophageal mucosa tissue were detected by immunohistochemical staining.The correlation between COX-2 and VEGF-C in cancer tissue was analyzed.The relationship between expression levels of COX-2,VEGF-C and clinicopathological features and prognosis were also analyzed.Results The positive expression rates of COX-2 and VEGF-C in esophageal cancer tissue were higher than those in adjacent normal esophageal mucosa tissue(P<0.05).Spearman correlation analysis showed that positive expression rate of COX-2 was positively correlated with positive expression rate of VEGF-C in esophageal cancer patients(r=0.388,P<0.05).The expression level of COX-2 was not related to gender,age or pathological types of esophageal cancer patients(P>0.05),but was related to differentiation degree,TNM staging and lymph node metastasis(P<0.05).The expression level of VEGF-C was not related to gender,age,pathological type or TNM staging(P>0.05),but was related to differentiation degree and lymph node metastasis(P<0.05).The 12-month survival rate of patients with positive COX-2 was lower than those with negative COX-2.The 12-month survival rate of patients with positive VEGF-C was lower than those with negative VEGF-C(P>0.05).There was no significant difference in 12-month recurrence rate among patients with different expression levels of COX-2 and VEGF-C(P>0.05).Conclusion The expression levels of COX-2 and VEGF-C in cancer tissue of esophageal cancer patients are high.And they are related to clinicopathological parameters.Their effects on prognosis are not significant.However,clinical detection of COX-2 and VEGF-C can still provide reference for esophageal cancer evaluation.