女性儿童和青少年肿瘤患者生育力保存研究进展

近年来随着儿童和青少年肿瘤远期生存率的不断提高,这些肿瘤患者的生育力保存受到越来越多人关注。化疗和放疗可能会损害儿童和青少年肿瘤患者的生育力,使其在成年后发生卵巢早衰和不孕的风险增大,严重影响了成年幸存者的生活质量。卵子冷冻是青春期后患者保存生育力的标准方案,卵巢组织冷冻是青春期前儿童保存生育力的主要方法。对于移植卵巢组织有肿瘤细胞种植风险的患者,卵泡体外培养和人工卵巢可能是未来生育力保存发展的方向。本文综述女性儿童和青少年肿瘤患者生育力保存的现状和研究进展,为临床工作和进一步研究提供参考。

Fertility preservation in female children and adolescents with cancer

With the increasing long-term survival rate of children and adolescents with cancer,the fertility preservation of these cancer patients is receiving more and more attention.Chemotherapy and radiotherapy may impair fertility of children and adolescents with cancer and lead to premature ovarian failure and infertility in adult survivors.Oocyte cryopreservation is the standard approach for postpubertal patients.Ovarian tissue cryopreservation is the main method for prepubertal patients.For patients with transplanted ovarian tissue at risk of oncologic reseeding,in vitro culture of follicles and artificial ovaries may be the future direction of fertility preservation.This article reviews the current status and research progress of fertility preservation in female children and adolescents with tumors,and provides references for clinical work and further research.