新鲜或冻融周期移植发育迟缓胚胎对卵巢低反应患者结局的影响

目的比较卵巢低反应(POR)患者新鲜或冻融周期移植发育迟缓的第3天胚胎对妊娠结局的影响。方法回顾性分析2015年1月至2018年8月在本中心行IVF/ICSI-ET且移植第3天发育迟缓胚胎的POR患者的临床资料。共343个周期,分为新鲜周期组(178例)和冻融周期组(165例),比较两组患者的一般情况、促排卵相关指标及临床妊娠率、种植率、流产率及活产率等指标。结果两组患者的一般情况、Gn总量和刺激时间、HCG日E₂水平和子宫内膜厚度、获卵数、可移植胚胎率、平均移植胚胎数、种植率及流产率等均无统计学意义(P>0.05)。与新鲜周期组相比,冻融周期组临床妊娠率和活产率均显著升高(P<0.05)。结论 POR患者选择冻融周期移植发育迟缓的胚胎可获得较好的临床妊娠结局。

Effect of transferring delayed development embryos in fresh or frozen-thawed cycles on pregnancy outcome in patients with poor ovarian response

Objective:To explore the effect of transferring Day3 delayed development embryos in fresh or frozen-thawed cycles on the pregnancy outcomes in the patients with poor ovarian response(POR).Methods:A retrospective study was performed in 343 IVF/ICSI-ET cycles transferring Day3 embryos with delayed development in POR patients in our reproductive center from January 2015 to August 2018.The cycles were divided into fresh cycles group(n=178)and frozen-thawed cycles group(n=165).The general characteristics,ovulation-related indicators,clinical pregnancy rate,implantation rate,abortion rate and live birth rate were compared between the two groups.Results:There were no significant differences in the general characteristics,doses and days of Gn used,E 2 level and endometrial thickness on HCG day,number of oocytes retrieved,available embryo rate,average number of embryos transfer,implantation rate,or abortion rate between the two groups(P>0.05).Compared with the fresh cycles group,the clinical pregnancy rate and live birth rate were significantly increased in the frozen-thawed cycles(P<0.05).Conclusions:The better clinical pregnancy outcome can be obtained in the POR patients with transferring the delayed cleavage-stage embryos in frozen-thawed cycles.