新型冠状病毒肺炎8例临床特点及转归分析

目的分析非武汉地区新型冠状病毒肺炎(COVID-19)患者的临床特点及转归情况。方法选取2020年1月21日至2020年2月8日在沈阳市中国医科大学附属第一医院隔离病房收治的8例COVID-19确诊患者为研究对象,收集临床资料,分析临床症状、辅助检查及转归情况。结果8例患者均有武汉旅居史或确诊患者接触史。临床表现为发热8例,咽痛1例,咳嗽3例,咳痰1例,乏力3例,肌肉酸痛3例,头痛2例,腹泻2例。入院时8例均为普通型,6例经治疗,好转出院;2例转为重型,病例特点为指氧饱和度渐降低,淋巴细胞数量持续低于正常,肺CT由磨玻璃密度伴实变影发展至双肺大片状实变影,经抗病毒、糖皮质激素及丙种球蛋白治疗后淋巴细胞数量、指氧饱和度恢复正常,肺CT实变影逐渐吸收。结论沈阳地区COVID-19患者均有明确流行病学史,临床主要表现为发热、咳嗽、乏力、肌肉酸痛等。重型患者表现为高热、咳嗽、淋巴细胞数量持续减低、指氧饱和度逐渐降低及肺CT迅速进展至大片状实变影,糖皮质激素、丙种球蛋白治疗有效。

Clinical characteristics and outcome analysis of 8 cases with COVID-19

Objective To investigate the clinical characteristics and outcome of patients with COVID-19 in Shenyang.Methods Data including clinical characteristics,outcome and laboratory index were obtained and analyzed in eight patients who were diagnosed with COVID-19 and admitted to the Fist hospital of China Medical University between January21,2020 to February 8,2020.Results All patients had epidemiology histories of sojourn in Wuhan or contacts with diagnosed patients.In 8 patients,symptoms were characterized by fever(8/8),sore throat(1/8),cough(3/8),phlegm(1/8),fatigue(3/8),muscular soreness(3/8),headache(3/8),and diarrhea(2/8).Among the 8 cases that were classified as common type at the period of admission,6 cases were cured and discharged.The other 2 cases exaggerated into severe,as characterized by the progressively decreased finger oxygen saturation and continuously lowered lymphocyte number.From chest CT imaging,lesions were characterized by the ground-glass shadow combined with consolidation,which further developed into large areas of consolidation bilaterally.After treatment with antiviral,glucocorticoid and gamma globulin,the number of lymphocytes and oxygen saturation returned to normal,as well,the consolidation presented on the chest CT imaging were absorbed.Conclusion All Patients with COVID-19 admitted in Shenyang hospital had direct epidemiological exposure history.The main clinical manifestations were fever,cough,fatigue and muscular soreness.Severe patients were presented with high fever,cough,continuously decrement of lymphocyte number,gradually decrement of finger oxygen saturation,and rapid progress to large areas of consolidation on chest CT scan.Glucocorticoid and gamma globulin were effective.