18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II |
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Authors: | Kenichiro Hamada Yasuhiko Tomita Ying Qiu Binglin Zhang Takafumi Ueda Akira Myoui Ichiro Higuchi Hideki Yoshikawa Katsuyuki Aozasa Jun Hatazawa |
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Institution: | Department of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. |
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Abstract: | Objective It remains controversial whether positron emission tomography (PET) with 2-deoxy-2-F-18]fluoro-d-glucose (F-18-FDG) can differentiate between benign and malignant musculoskeletal tumors. To uncover the mechanism of F-18-FDG
accumulations, we analyzed the correlation between the F-18-FDG accumulation and the expression of glucose transporter 1 (Glut-1)
and hexokinase II (HK-II) in benign and malignant musculoskeletal tumors.
Methods The maximum standardized uptake values (SUVmax) of F-18-FDG in 24 benign and 26 malignant musculoskeletal tumors were compared with the histologic malignancies, and the
expression of Glut-1 and HK-II was analyzed by immunohistochemistry.
Results The SUVmax for malignant tumors (6.33 ± 4.79) was significantly higher than those with benign tumors (3.47 ± 3.12, P < 0.01). The expression of Glut-1 was high in 12 patients (all malignant) and low in 38 patients (24 benign and 14 malignant),
and the expression of HK-II was high in 36 patients (11 benign and 25 malignant) and low in 14 patients (13 benign and 1 malignant).
Cases with high expression of Glut-1 and HK-II at immunohistochemistry showed a higher SUVmax than those with low expression (Glut-1 8.03 ± 5.10 and 3.98 ± 3.53, P < 0.01; HK-II 5.73 ± 4.49 and 2.99 ± 3.02, P < 0.01). No significant dividing threshold of the SUVmax of F-18 FDG was found for the differential diagnosis between benign and malignant tumors or for the expression of Glut-1
and HK-II.
Conclusions The limited capability of F-18 FDG-PET in the differential diagnosis of musculoskeletal tumors is owing partly to the various
levels of Glut-1 and HK-II expression in individual tumors. |
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Keywords: | Positron emission tomography Maximum standardized uptake values Glucose transporter 1 Hexokinase II Musculoskeletal tumor |
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