肥胖大学生体质量指数相关因素分析

目的探讨肥胖大学生体质量指数与血清同型半胱氨酸、氧化低密度脂蛋白、血脂及血糖的相关性及其临床意义。方法 2010年入学体检大学生中以自愿参加方式,将体质量指数≥25的大学生55例设为肥胖组(n=55),体质量指数<25的大学生92例设为对照组(n=92),2组学生均无急慢性内科疾患。直接竞争ELISA法测定2组血清同型半胱氨酸、氧化低密度脂蛋白水平,测定总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血糖。结果 2组比较,肥胖组血清同型半胱氨酸高于对照组,氧化低密度脂蛋白高于对照组,差异均有统计学意义(P<0.05);肥胖组血清三酰甘油高于对照组,高密度脂蛋白低于对照组,差异有统计学意义(P<0.01);2组总胆固醇、低密度脂蛋白、血糖差异无统计学意义(P>0.05);肥胖组大学生体质量指数与血清同型半胱氨酸水平相关(r=0.321,P<0.05),体质量指数与血清氧化低密度脂蛋白水平不相关(r=0.263,P>0.05);多元线性回归分析显示,三酰甘油、同型半胱氨酸为肥胖组大学生体质量指数水平的独立影响因素。结论肥胖大学生易发生动脉粥样硬化性疾病。防治大学生肥胖及相关慢性病,是高校教育需重视的问题。

Related factors of body mass index in obese college students

Objective To investigate the correlation of body mass index(BMI) with plasma homocysteine(Hcy),oxidized low density lipoprotein(OX-LDL),TC,TG,LDL-c,HDL-c,and GLU in obese college students and their clinical significance.Methods A total of 147 new college students of 2010 who were volunteers were included.The subjects were divided into two groups according to BMI:an obese group(BMI≥25,n=55) and a control group(BMI< 25,n=92).The levels of Hcy and OX-LDL were measured by ELISA,and the levels of serum lipids and glucose were measured by routine assays.Results The levels of plasma Hcy and ox-LDL in the obese group were higher than those in the control group(P<0.05),TG was higher(P<0.01),and HDL-c was lower(P<0.01).There was a significant correlation between the Hcy level and BMI,but there was no correlation between the ox-LDL level and BMI.The multiple regression analysis showed that TG and Hcy were the independent factors to BMI in obese college students.