2型糖尿病患者颈动脉粥样硬化与血糖血脂水平的关系

目的探讨2型糖尿病患者颈动脉粥样硬化程度与血糖、血脂等因素的相关性。方法对100例2型糖尿病初诊患者和40例我院血糖正常的健康体检者(对照组)行颈动脉超声检查,测定颈动脉内-中膜厚度(IMT)平均值及粥样硬化斑块情况,同时测定患者糖化血红蛋白(HbA1c)、血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]等项目,分析糖尿病患者颈动脉硬化情况与血糖、血脂的关系。结果 100例糖尿病患者有不同程度颈动脉粥样硬化者占75%(75例),明显高于健康对照组(25%,P<0.01)。糖尿病有斑块组IMT平均为(1.42±0.21)mm,糖尿病无斑块组IMT平均为(1.00±0.18)mm,两组比较差异有统计学意义(P<0.01)。糖尿病有斑块组患者的HbA1c、LDL-C水平明显高于和HDL-C水平明显低于无斑块组患者[HbA1c:8.1%±1.6%比6.2%±1.8%;LDL-C:(4.8±0.9)mmol/L比(4.2±0.8)mmol/L;HDL-C:(0.8±0.3)mmol/L比(1.0±0.5)mmol/L,均为P<0.05]。结论糖尿病患者颈动脉硬化的程度与血糖、血脂水平存在显著的相关性。

Relationship between carotid atherosclerosis and plasma lipids and glucose in patients with type 2 diabetes

Objective To study the relationship between carotid atherosclerosis and plasma lipids and glucose in patients with type 2 diabetes. Methods A total of 100 patients with type 2 diabetes and 40 healthy controls were enrolled.Carotid artery intima-media thickness(IMT) was detected by Ultrasonography and blood HbA1c,plasma lipids(TC,TG,LDL-C,HDL-C) were measured for all subjects. Results The incidence of carotid atherosclerosis in type 2 diabetes patients was significantly higher than in healthy controls(75% vs.25%,P<0.01).The mean IMT of Type 2 diabetes patients with carotid artery plaque was significantly greater than those without [(1.42±0.21)mm vs.(1.00±0.18)mm,P<0.01].Type 2 diabetes patients with carotid atherosclerosis plaque had higher blood HbA1c and LDL-C,and lower HDL-C(all P<0.05) than those without plaque and healthy controls(all P<0.05). Conclusions The extent of carotid atherosclerosis is positively correlated with blood glucose and lipids in patients with type 2 diabetes.