血管紧张素转换酶2基因A9570G多态性与高血压合并左心室肥厚的相关性研究

目的探讨血管紧张素转换酶2基因(ACE2)A9570G多态性与高血压合并左心室肥厚的关系。方法选择高血压合并左心室肥厚(LVH)患者172例(LVH组)、高血压未合并LVH患者153例(NLVH组)以及对照组80例,应用聚合酶链反应(PCR)方法检测入选者ACE2基因A9570G多态性,按性别分别比较不同组别中基因型分布及等位基因频率的差异。结果在女性,3组间等位基因频率比较差异有统计学意义(P=0.007),基因型分布差异也有统计学意义(P=0.034),其中LVH组GG基因型及G等位基因频率分别为30.0%和61.0%,高于NLVH组(18.7%和44.8%)及对照组(15.0%和40.0%)。在男性,3组间等位基因/基因型频率比较差异有统计学意义(P=0.002),其中LVH组G基因型/等位基因频率为69.0%,高于NLVH组(47.6%)及对照组(40.0%)。结论 ACE2基因A9570G多态性与高血压患者左心室肥厚相关。

Association between polymorphism of angiotensin converting enzyme 2 gene A9570G and hypertension with left ventricular hypertrophy

Objective To investigate the association between polymorphism of angiotensin converting enzyme 2(ACE2) gene A9570G and hypertension with left ventricular hypertrophy(LVH). Methods One hundred and seventy-two hypertension patients with LVH(LVH group) and 153 without LVH(NLVH group),and 80 healthy subjects(control group) were included in this study.The polymorphisms of ACE 2 gene were measured by polymerase chain reaction(PCR).Genotype distribution and allele frequency in different groups were compared. Results In women,both allele frequency(P=0.007) and genotype distribution(P=0.034) were significantly different among the three groups.GG genotype distribution and G allele frequencies in LVH group were significantly higher(30.0% and 61.0%) than in NLVH group(18.7% and 44.8%) or in control group(15.0% and 40.0%,both P<0.05).In men,allele frequency and genotype distribution were significantly different among the three groups(P=0.002).GG genotype/G allele frequencies in LVH group(69.0%) was significantly higher than in NLVH group(47.6%) and control group(40.0%,all P<0.05). Conclusions The polymorphism of A9570G in ACE2 gene may be associated with hypertension with LVH.