Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, α-cyclodextrin and quaternary chitosan N-betainate |
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| Authors: | Janne Mannila,Kristiina Jä rvinen,Jukka Holappa,Laura Matilainen,Seppo Auriola,Pekka Jarho |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland;2. Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland |
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| Abstract: | Systemic drug delivery through intraoral membranes may offer a promising administration route for lipophilic peptide drugs. The aim of the present study was to investigate the effect of α-cyclodextrin (α-CD) and a novel chitosan derivative, chitosan N-betainate (CH), on sublingual absorption of a hydrophobic model peptide cyclosporin A (CsA), and the effect of temperature on the complexation of CsA with α-CD. |
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| Keywords: | Absorption enhancer Bioavailability Buccal Cyclodextrins Peptide delivery Transmucosal drug delivery |
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