Anti-inflammatory and anti-pyretic activities of earthworm extract—Lampito mauritii (Kinberg) |
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Authors: | M Balamurugan K Parthasarathi EL Cooper LS Ranganathan |
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Institution: | 1. Division of Vermibiotechnology, Department of Zoology, Annamalai University, Annamalai Nagar 608002, India;2. Laboratory of Comparative Immunology, Department of Neurobiology, UCLA Medical Centre, University of California, Los, Angeles, CA 90095-1763, USA;3. VLB Janakiammal College of Arts and Science, Kovaipudur, Coimbatore 641042, India |
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Abstract: | Aim of the studyExperiments were conducted to understand the therapeutic properties such as anti-inflammatory and anti-pyretic activities of biologically active extract isolated from whole earthworm (Lampito mauritii, Kinberg).Materials and methodsInflammation in the hind paw of Wistar albino rat, Rattus norvegicus, was induced by histamine, granuloma pouch was induced by turpentine and pyrexia induced by Brewer's yeast in rats were followed as earlier studies. Anti-inflammatory drug—indomethacin and anti-pyretic drug—paracetamol were used as standard drug for comparison.ResultsAdministration of indomethacin (10 mg/kg), paracetamol (150 mg/kg) and/or different doses of earthworm extract (EE) (50, 100 and 200 mg/kg) reduced and restored to normal conditions in a dose-dependent manner of histamine and turpentine induced inflammation, and Brewer's yeast induced pyretic in rats.ConclusionsThe most significant inhibition of paw oedema and granuloma and also the significant reduction in hyperpyrexia in rats when treated with standard drugs as well as different doses of EE, reflect the presence of anti-inflammatory and anti-pyretic properties of EE similar to glycoprotein complex (G-90). |
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Keywords: | Earthworm extract Anti-inflammation Anti-pyretic Therapeutic agent |
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