| 兔动脉粥样硬化不同阶段血管内膜、血小板和高胆固醇血症的相互作用 |
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| 引用本文： | 何作云,于学军,尹翠娥,肖桃元.兔动脉粥样硬化不同阶段血管内膜、血小板和高胆固醇血症的相互作用[J].高血压杂志,1993(2). |
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| 作者姓名： | 何作云 于学军 尹翠娥 肖桃元 |
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| 作者单位： | 第三军医大学新桥医院心血管病科 重庆630037 |
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| 基金项目： | 国家自然科学基金会资助项目!(编号 93880 0 30 0 ) |
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| 摘 要： | 在高胆固醇饲料复制的兔主动脉微小病灶期、脂纹期、纤维—脂质斑块期和纤维—粥样斑块期的各型病变中 ,血小板Ca2 ] i浓度逐渐升高 ,血小板内 c A MP水平趋于降低 ,两者呈密切负相关 (r=-0 .6 6 7,P<0 .0 0 1)。
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| 关 键 词： | 动脉粥样硬化 兔 血小板 钙 |
Interaction of Vessel Endothelium,Platelets and Hypercholesterolemia in Rabbits at Various Stages of Atherosclerosis |
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| Abstract: | Concentration of cytosolic free Ca\ \{2 \}]i was elevated and level of cAMP declined progressively in platelets in the course of atherosclerosis from the phase of minute focal lesion,fatty streaks,fibro lipid plaque to fibroatheromatous plaque in cholesterol fed rabbits.Ca\ \{2 \}]i concentration negatively correlated with the level of cAMP (r=-0.667,P<0.001).Increase in Ca\ \{2 \}]i may be associated with decreased level of cAMP by a negative feedback.The results indicate that the interaction of endothelial injury,platelet activation and hypercholesterolemia plays an important role in the pathogenesis of atherosclerosis in cholesterol fed rabbits. |
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| Keywords: | atherosclerosis rabbit platelet calcium |
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