心力衰竭患者心功能与血浆Apelin水平的关系

目的研究心力衰竭（简称心衰，HF）患者血浆活性肽Apelin浓度与心功能的关系，探讨心衰发生、发展的病理生理机制。方法选择住院心衰患者52例作为心衰组，门诊健康体检者59例作为对照组。所有受试者采集静脉血，应用酶联免疫吸附法（ELISA）测定血浆Apelin含量。用SPSS11．5软件对数据进行分析。结果Apelin水平比较：心衰组明显低于对照组[（0．4074±0．1607）ng／ml比（0．5299±0．2613）ng／ml，P〈0．01]，差异有统计学意义。心功能与血浆Apelin浓度的关系：心衰Ⅲ级、Ⅳ级组Apelin水平低于Ⅱ级组[（O．3416±0．0911）ng／ml，（O．2998±0．1049）ng／ml比（O．4546±0．1172）ng／ml，P均〈O．05]，差异有统计学意义。Ⅳ级组略低于Ⅲ级组，但二者之间差异无统计学意义（P〉O．05）。结论慢性心衰患者血浆Apelin水平降低，且与心衰的严重程度呈负相关。提示Apelin与心衰的发生、发展有一定的关系。

Changes in plasma Apelin congentrations in patients with heart failure

Objective To detect the plasma concentration of the peptide Apelin in patients with heart failure with enzyme linked immunosorbent assay （ELISA） and observe its changes at differents cardiac status. Methods 52 hospital patients with HF were divide into 3 subsets according to the NYHA： Ⅱ group, Ⅲ group and IV group. 59 healthy persons were ehoosed as the control group. Plasma Apelin concentrations were measured with ELISA before treatment. Results The plasma Apelin concentration in patients with HF were signitieantly lower than that of the control group [ （0.5299±0.2613）ng/ml vs （0.4074±0.1607）ng/ml,P〈0.01 ]. The Apelin con- eentration of Ⅲ and IV group were lower than that of Ⅱ group （0.3416±0.0911,0.2998±0.1049 vs 0.4546± 0.1172,P〈0.05 ）. But the difference between Ⅲ and IV group is not statistically significant（P〉0.05 ）. Conclusion Plasma Apelin concentrations are decreased in patients with HF. The Apehn-APJ signaling pathway may be a po- tentially important mediator in the pathophysiological processes of heart failure.