原发性骨肉瘤的组织学分型及免疫组化研究

报道65例骨肉瘤组织学分型和免疫组化研究的结果。组织学上区分为以下类型:骨母细胞型(11例,16.92％),软骨母细胞型(8例,12.30％),纤维母细胞型(11例,16.92％),恶纤组型(8例,12.30％),巨细胞型(5例,7.69％),小细胞型(3例,4.62％),上皮样型(2例,3.08％),毛细血管扩张型(2例,3.08％),骨内分化好型(5例,7.69％),透明细胞型(3例,4.62％),骨旁骨肉瘤(4例,6.15％),骨膜骨肉瘤(1例,1.54％),高度恶性表面骨肉瘤(2例,3.98％)。本组对恶纤组型、巨细胞型各1例进行超微结构观察,20例作免疫组化及酶组化染色。较详细地讨论了骨肉瘤的组织学分型。

Histologic Typing and Immunohistochemical Stuies of Primary Osteosarcoma

Sixty five cases with osteosarco-ma are reproted. Histologically, the tumors were divided into 10 variants: osteoblaslic osteosarcoma (11 cases, 16.92%), chon-drobiastic osteosarcoma(8 cases, 12. 30%), fibroblastic osteosarcoma (11 cases, 16.92%), malignant fibrous histiocytoma typic osteosarcoma (8 cases, 12.30%), giant cell typic osteosarcoma ( 5 cases, 7.69%), small cell typic osteosarcoma (3 cases, 4.62%), epithlioid cell typic osteosarcoma (2 cases, 3.08%), telangiectat-ic osteosarcoma (2 cases, 3.08), in-traosseous well-diffirentiated osteosarcoma(5 cases, 7.69%), clear cell typic ostesar-coma (3 case, 4. 62%) ,parosteal osteosarcoma (4 cases, 6.15%), periosteal osteosarcoma (1 case, 1.54%), high-grade surface osteosarcoma (2 cases, 3.08%). One case of MFH-type and giant cell type were studed respectively by electromi-croscopy. Twenty cases were stained with enzyme-or immuno-histochemic methods. The histologic typing of osteosarcoma is discussed.