阻塞型睡眠呼吸暂停综合征合并高尿酸血症与脑梗死的临床研究

目的研究高尿酸血症对阻塞型睡眠呼吸暂停综合征(OSAHS)的影响,探讨与脑梗死之间的相关性。方法选取OSAHS患者111例,测定血尿酸(UA)、血脂等生化指标,分为高尿酸血症组(观察组)及非高尿酸血症组(对照组),分析两组睡眠监测指标、OSAHS严重程度及头颅CT。结果观察组AHI、SaO2检测结果低于对照组,但差异无统计学意义(P>0.05);两组OSAHS严重程度比较无差异(P>0.05);观察组脑梗死发生率明显高于对照组(P<0.01)。结论高尿酸血症对OSAHS病情影响不明显,对OSAHS患者发生脑梗死有一定的促进作用,控制血尿酸水平可降低OSAHS患者脑梗死的发生率。

Clinical study of relationship between patients with obstructive sleep apnea hypopnea syndrome complicated with hyperuricemia and cerebral infarction

Objective To study the relationship between hyperuricemia in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS） and cerebral infarction.Methods 111 patients with OSAHS were selected to detect the blood uric acid and blood fat.Then they were divided into the hyperuricemia group（the observation group） and the non-hyperuricemia group（the control group）.Sleep-monitoring,severity of OSAHS and head CT were analyzed between the two groups.Results The levels of AHI and SaO2 were lower in the observation group than in the control group without statistical significance（P〈0.05）.There was no significant difference on the severity of OSAHS between the two groups（P〈0.05）.The incidence of cerebral infarction was obviously higher in the observation group than in the control group（P 0.01）.Conclusion The effect of hyperuricemia to OSAHS disease is not obvious,but hyperuricemia plays an important role in the occurrence of cerebral infarction in OSAHS patients.It is possible to reduce incidence of cerebral infarction by controlling the level of blood uric acid strictly.