脑脊液Cystatin C在脑膜脑炎诊断中的价值探讨

目的:探讨脑脊液胱氨酸蛋白酶抑制剂C(Cystatin C)在脑膜脑炎诊断中的临床价值。方法:检测51例脑膜炎、30例脑膜脑炎、42例脑炎患者及21例正常对照组脑脊液Cystatin C、总蛋白(TP)、葡萄糖(Glu)及氯化物(Cl)水平,以评价脑脊液中Cystatin C在脑膜脑炎诊断中的价值。结果:脑膜脑炎组Cystatin C(3.68±1.19 mg/L)较正常对照组(5.40±1.15mg/L)及脑膜炎组(5.08±1.42 mg/L)显著降低(p<0.01),与脑炎组(3.61±1.48 mg/L)比较无显著差异(p>0.05)。结论:脑脊液中Cystatin C联合Glu、Cl及TP对脑膜脑炎的诊断有一定价值。

Value of CSF Cystatin C in the Diagnosis of Meningocephalitis

Objective： To explore the clinical value of cerebrospinal fluid（CSF） cystatin C level in the diagnosis of meningocephalitis.Methods： CSF samples were collected from patients with meningitis（51 cases）,meningoencephalitis（30 cases）,encephalitis（42 cases） and normal controls（21 cases）.The levels of cystatin C,total protein（TP）,glucose（Glu） and chloride（Cl） in CSF were measured.Results：CSF cystatin C levels were lower in the patients with meningocephalitis（3.68±1.19 mg/L） than those in the controls（5.40±1.15mg/L） or meningitis（5.08±1.42 mg/L）（p〈0.01）.There was no difference with the level of cystatin C between meningoencephalitis and encephalitis（3.61±1.48mg/L）.Conclusions：Combination of glucose,chloride and TP measurement,decreased level of cystatin C in CSF may help the diagnosis of meningocephalitis.