Involvement of thermosensitive TRP channels in energy metabolism |
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| Authors: | Kunitoshi Uchida Katsuya Dezaki Takeshi Yoneshiro Tatsuo Watanabe Jun Yamazaki Masayuki Saito Toshihiko Yada Makoto Tominaga Yusaku Iwasaki |
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| Institution: | 1.Division of Cell Signaling, Okazaki Institute for Integrative Biosciences (National Institute for Physiological Sciences),National Institutes of Natural Sciences,Okazaki,Japan;2.Department of Physiological Sciences,SOKENDAI (The University of Advanced Studies),Okazaki,Japan;3.Department of Physiological Science and Molecular Biology,Fukuoka Dental College,Fukuoka,Japan;4.Division of Integrative Physiology, Department of Physiology,Jichi Medical University School of Medicine,Shimotsuke,Japan;5.Diabetes Center,University of California, San Francisco,San Francisco,USA;6.Faculty of Future Industry,Happy Science University,Chiba,Japan;7.Hokkaido University,Sapporo,Japan |
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| Abstract: | To date, 11 thermosensitive transient receptor potential (thermo-TRP) channels have been identified. Recent studies have characterized the mechanism of thermosensing by thermo-TRPs and the physiological role of thermo-TRPs in energy metabolism. In this review, we highlight the role of various thermo-TRPs in energy metabolism and hormone secretion. In the pancreas, TRPM2 and other TRPs regulate insulin secretion. TRPV2 expressed in brown adipocytes contributes to differentiation and/or thermogenesis. Sensory nerves that express TRPV1 promote increased energy expenditure by activating sympathetic nerves and adrenaline secretion. Here, we first show that capsaicin-induced adrenaline secretion is completely impaired in TRPV1 knockout mice. The thermogenic effects of TRPV1 agonists are attributable to brown adipose tissue (BAT) activation in mice and humans. Moreover, TRPA1- and TRPM8-expressing sensory nerves also contribute to potentiation of BAT thermogenesis and energy expenditure in mice. Together, thermo-TRPs are promising targets for combating obesity and metabolic disorders. |
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