Resolution of sinus bradycardia,high‐grade heart block,and left ventricular systolic dysfunction with rituximab therapy in Henoch‐Schonlein purpura |
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Authors: | Mikhail Torosoff Thomas Breen Sujata Balulad Santosh Padala Radmila Lyubarova Henry Tan Mandeep Sidhu |
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Affiliation: | 1. Albany Medical Center, Albany, New York, USA;2. Mount Sinai Hospital, New York, New York, USA;3. Virginia Commonwealth University Medical Center, Richmond, Virginia, USA |
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Abstract: | Henoch‐Schonlein purpura (HSP) is a rare, typically self‐limited, multi‐organ vasculitis. Cardiac involvement with HSP carries high morbidity and mortality, thus requiring early aggressive immunosuppressive therapy. We report a case of HSP complicated with acute systolic left ventricular (LV) dysfunction, symptomatic sinus bradycardia and high‐grade atrio‐ventricular (AV) heart block. Cyclophosphamide, a commonly used agent in HSP, was contraindicated due to the patient's presentation with acute renal failure. Treatment with monoclonal antibody rituximab and corticosteroids was initiated with an improvement in and resolution of LV systolic dysfunction, sinus bradycardia and AV block. We believe this is the first published report on rituximab treatment in HSP with cardiac involvement manifesting with severe LV systolic dysfunction, sinus bradycardia and high‐grade AV block. |
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Keywords: | Henoch‐Schonlein purpura vasculitis heart block arrhythmia left ventricular systolic dysfunction rituximab |
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