Examination of the relationship between disease activity and patient‐reported outcome measures in an inflammatory bowel disease cohort |
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| Authors: | Belinda D Jackson Danny Con Alexandra Gorelik Danny Liew Simon Knowles Peter De Cruz |
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| Institution: | 1. Department of Gastroenterology, The Austin Hospital, Melbourne, Victoria, Australia;2. Department of Medicine, Austin Academic Centre, The University of Melbourne, Melbourne, Victoria, Australia;3. Melbourne EpiCentre, Royal Melbourne Hospital, Melbourne, Victoria, Australia;4. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia;5. Department of Psychology, Swinburne University of Technology, Melbourne, Victoria, Australia;6. Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia |
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| Abstract: | Background The extent to which disease activity impacts patient‐reported outcomes (PRO) is unclear. Aims To examine the relationship between disease activity and PRO. Methods Adult inflammatory bowel disease (IBD) patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (Simple Clinical Colitis Activity Index (SCCAI), Harvey Bradshaw Index (HBI)), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (Hospital Anxiety and Depression Scale (HADS)), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PRO. Results A total of 81 participants was included: 49% female, 57% Crohn disease (CD), 38% ulcerative colitis (UC) and 5% IBD‐unclassified, with a median age of 34 years. At least mild levels of depression were present in 21 of 81 (26%) of patients; 37 of 81 (46%) expressed some level of anxiety. A moderate‐to‐strong correlation was found between disease activity and depression in UC (r = 0.84, P = 0.002) but not in CD (r = 0.53, P = 0.29). Disease activity correlated with: overall work impairment due to health (r = 0.85, P = 0.001), health‐related impairment while working (r = 0.76, P = 0.02) and percentage of activity impaired due to health (r = 0.83, P = 0.002) in UC only. Conclusions Disease activity significantly affects mood and work productivity in patients with UC. Monitoring patients’ ability to function and work, rather than minimising disease activity alone, should become a routine part of IBD care. |
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| Keywords: | ulcerative colitis Crohn disease inflammatory bowel disease patient‐reported outcomes work productivity |
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