Spontaneous expression of fra(10)(q25) in bone marrow from a patient with agranulocytosis |
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| Authors: | S M Haney F O Butler N A Heerema |
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| Institution: | Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223. |
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| Abstract: | We report on the spontaneous expression of fra(10)(q25) in bone marrow from a patient with agranulocytosis. Expression of this fragile site in both bone marrow and leukocytes was enhanced by bromodeoxyuridine (BrdU), while folic-acid-deficient medium enhanced the expression of fra(10)(q25) only in leukocytes. Variability in the expression of fra(10)(q25) in bone marrow and leukocyte cultures over an 18-month period was also found. |
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