| 抗光敏合剂对BALB/C小鼠急性光损伤所致表皮细胞炎症损伤干预作用的研究 |
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| 引用本文： | 孙丽蕴,张广中,李蜀平,刘魁英,娄卫海,王萍,王兢.抗光敏合剂对BALB/C小鼠急性光损伤所致表皮细胞炎症损伤干预作用的研究[J].中国中医基础医学杂志,2012(7):743-744. |
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| 作者姓名： | 孙丽蕴 张广中 李蜀平 刘魁英 娄卫海 王萍 王兢 |
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| 作者单位： | 首都医科大学附属北京中医医院;北京市中药研究所 |
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| 基金项目： | 北京市教育委员会科技计划项目-抗光敏合剂对皮肤红斑狼疮光敏感的干预研究(KM200910025026);北京市优秀人才资助项目-抗光敏合剂对UVB光损伤干预作用的研究(2009D003007000001);北京市中医管理局青年科学研究资助项目-抗光敏合剂治疗光毒侵袭证多形性日光疹的随机对照临床研究(QN2011-01);首都医科大学校长研究基金项目-中医皮肤病学教学形象化课件制作的探讨(11JYY106);国家中医药管理局中医皮肤病学重点学科、国家临床重点专科(中医皮肤科专业) |
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| 摘 要： | 目的:观察抗光敏合剂对急性UVB辐射后BALB/c小鼠皮肤炎症细胞损伤的影响,以探讨抗光敏合剂对皮肤光损伤的作用机理。方法:以300mJ/cm2UVB辐射BALB/c小鼠建立急性光损伤模型,在预防性应用中药抗光敏合剂后,与正常小鼠、预防性应用生理盐水及羟氯喹小鼠进行平行对照研究。HE染色法观察炎症变化程度,并以病理图片处理系统观察小鼠表皮厚度。结果:动物实验研究结果显示,中药抗光敏合剂可以缓解急性UVB辐射损伤造成的细胞炎症反应,保护角质形成细胞,发挥对急性光损伤保护的作用机制。结论:抗光敏合剂治疗可明显缓解紫外线引起的表皮角质形成细胞的炎性损害,从而发挥其治疗作用。
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| 关 键 词： | 抗光敏合剂 光损伤与光保护 |
Effect of the anti-photosensitivity mixture on the inflammation of epidermal cells of BALB/c mice induced by UVB |
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| SUN-Li-yun,ZHANG Guang-zhong,LI Shu-ping,LIU Kui-ying,LOU Wei-hai,WANG Ping,WANG Jing.Effect of the anti-photosensitivity mixture on the inflammation of epidermal cells of BALB/c mice induced by UVB[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,2012(7):743-744. |
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| Authors: | SUN-Li-yun ZHANG Guang-zhong LI Shu-ping LIU Kui-ying LOU Wei-hai WANG Ping WANG Jing |
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| Institution: | .(Department of Dermatology,The Traditional Chinese Medical Hospital of Beijing, The Beijing Institution of Traditional Chinese Medical.Beijing 100010,China) |
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| Abstract: | Objective:To investigate the influence of anti-photosensitivity mixture to the inflammation of epidermal cells of BALB/c mice irradiated by UVB.Methods:BLAB/c mice were divided into treatment group,negative and positive control groups,and then irradiated with UVB in dosages of 300 mJ/cm2 for once.The HE stained cells were detected.Results:At experimental research,anti-photosensitivity mixture can reduce the inflammation of damage cells.Conclusions:According to the result,anti-photosensitivity mixture showed that it could treat the photosensitivity effectively,with the mechanism of relieving the inflamed of reaction. |
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| Keywords: | anti-photosensitivity mixture inflammation effection |
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