胺碘酮治疗老年室性心律失常的临床疗效及安全性

目的 分析胺碘酮治疗老年室性心律失常患者的临床疗效及安全性.方法 将136例年龄≥65岁室性心律失常患者随机分为观察组和对照组各68例,两组患者在试验前10 d均停用其他抗心律失常药物.对照组患者给予相关病因综合治疗,观察组在对照组治疗基础上应用胺碘酮200 mg,口服,3次/d.根据患者情况,7d后改为200 mg,2次/d.7d后,再改为200 mg,1次/d,维持到患者心律失常控制,而后给予每天50 mg维持,两组患者均治疗4周.结果 治疗后观察组显效率、总有效率分别为51.47％、92.65％,均显著高于对照组的51.47％、92.65％ （P ＜0.05）,两组不良反应发生率差异无统计学意义（P＞0.05）.结论 胺碘酮能够显著控制老年患者室性心律失常,临床效果显著,不良反应少,是一种能有效抑制心律失常,又不会促发心律失常的药物.

The clinical efficacy and safety of amiodarone in the treatment of elderly patients with ventricular arrhythmia

Objective To analyze the clinical efficacy and safety of amiodarone in the treatment of the elderly patients with ventricular arrhythmia. Methods 136 elderly patients with ventricular arrhythmia were randomly divided into the observation group（ n = 68cases） and control group（ n = 68cases）. The observation group was given amiodarone by intravenous to treat the elderly ventricular arrhythmia, and patients in the control group were treated with combination therapy. After treatment for 4 weeks,the treatment outcomes were observed and compared. Results The obvious effective rate and total effective rate of the observation group was 51.47% ,92.65% ）. which were significant- ly higher than those in the control group （51.47 %, 92.65 % ） （ P 〈 0.05 ）. There was no significant difference in the incidence rate of adverse effect between the two groups （ P 〉 0.05）. Conclusion Amiodarone has good clinical effect in treatment of elderly patients with ventricular arrhythmia,it is worthy of clinical use.