Longitudinal growth attainments of Indian boys with Juvenile Rheumatoid Arthritis |
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Authors: | Bimal Aggarwal Anil K Bhalla Surjit Singh |
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Institution: | (1) Child Growth and Anthropology Unit, Advanced Pediatrics Centre, Chandigarh, 160012, India;(2) Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Chandigarh, 160012, India;(3) Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India; |
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Abstract: | The objective is to study the pattern of distance and velocity growth in terms of weight and height in adolescent boys with
Juvenile Rheumatoid Arthritis (JRA). This study was conducted on children diagnosed to have JRA (Cassidy and Petty in Juvenile
Rheumatoid Arthritis, WB Saunders Co., Philadelphia, 2005) at the Pediatric Rheumatology and Immunology Clinic of Advanced
Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. A total of 203 observations made
on 70 boys with JRA, between 9 and 17 years of age, comprised the sample for this prospective mixed-longitudinal growth study.
Each subject was measured for body weight and standing height using standardized anthropometric techniques (Eveleth and Tanner
in Worldwide variation in human growth, Cambridge University Press, New York, 1990) at half yearly age intervals. All anthropometric
measurements were carried out in the Growth Laboratory of Advanced Pediatrics Centre. Boys with polyarticular and systemic
onset types of JRA in general measured lighter than their pauciarticular counterparts throughout the period of study. Height
attainments in boys with polyarticular and systemic onset JRA measured shorter than their pauciarticular counterparts till
15 years and 12 years, respectively, where-after they became comparable to boys with pauciarticular JRA. As compared to normal
Indian (Bhalla and Kumar in Int J Anthropol 18:113–125, 2003; Aggarwal et al. in Indian Pediatr 29:1203–1282, 1992) and American
(Ogden et al. in Pediatrics 109:45–60, 2002) counterparts boys representing all categories of JRA remained lighter and shorter.
Onset of Peak Height Velocity (PHV) in boys with polyarticular JRA (i.e. 12.5 years) was delayed by 1 year as compared to
boys with pauciarticular JRA (i.e. 11.5 years). Attainment of Peak Weight Velocity (PWV) in boys with polyarticular JRA (i.e.
13.5 years) was also delayed by 1 year when compared to those with pauciarticular type (i.e. 12.5 years). In conclusion, weight
and height growth attainments in Indian adolescent boys afflicted with different categories of JRA in general remained impaired
as compared to their normal counterparts. However, the magnitude of growth deficit experienced by them appears to be a disease
severity related phenomenon. This is the first study of its kind from a developing country. |
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