| 美托洛尔对充血性心力衰竭大鼠血浆醛固酮浓度、心肌纤维化和心室重构的影响 |
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| 引用本文： | 蔡辉,李筝,焦东东,郭郡浩,郭寒.美托洛尔对充血性心力衰竭大鼠血浆醛固酮浓度、心肌纤维化和心室重构的影响[J].微循环学杂志,2010,20(1):13-15,F0003. |
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| 作者姓名： | 蔡辉 李筝 焦东东 郭郡浩 郭寒 |
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| 作者单位： | 南京军区南京总医院中西医结合科,南京,210002 |
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| 基金项目： | 南京军区南京总医院科研基金资助项目 |
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| 摘 要： | 目的:探讨美托洛尔对充血性心力衰竭(CHF)大鼠血浆醛固酮(ALD)浓度的影响及防治心肌纤维化及心室重构的作用。方法:雄性SD大鼠30只,随机选择20只皮下注射异丙基肾上腺素二次(170mg/kg/次),6周后左室射血分数≤45%确定造模成功;将模型大鼠随机分为模型组(n=10)和美托洛尔治疗组(n=10,8mg/kg/天,共治疗12周);另10只大鼠作为正常对照组。18周后进行心功能指标、血浆ALD浓度检测,并取心肌观察组织形态学及胶原纤维染色。结果:(1)与对照组相比,模型组心功能指标明显恶化,血浆ALD显著升高(P0.01),心肌纤维化和心室重构明显;(2)与模型组比较,美托洛尔组心功能明显好转,血浆ALD明显下降(P0.01),心肌纤维化和心室重构明显改善。结论:美托洛尔能通过降低CHF大鼠血浆ALD浓度而改善心功能,逆转心室重塑。
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| 关 键 词： | 充血性心力衰竭 血浆醛固酮 心肌纤维化 美托洛尔 心室重构 肾素一血管紧张素系统 心肌间质纤维化 心血管疾病 |
Effect of Metoprolol on Change of Plasma Aldosterone,Myocardium Fibrosis and Myocardial in Rats with Remodeling Congestive Heart Failure |
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| Cai Hui,Guo Han,Li Zheng,et al.Effect of Metoprolol on Change of Plasma Aldosterone,Myocardium Fibrosis and Myocardial in Rats with Remodeling Congestive Heart Failure[J].Chinese Journal of Microcirculation,2010,20(1):13-15,F0003. |
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| Authors: | Cai Hui Guo Han Li Zheng |
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| Institution: | Cai Hui,Guo Han,Li Zheng,et al Department of Integrated Traditional Chinese , Western Medicine,Nanjing General Hospital of Nanjing Military Comm,,Nanjing 210002 |
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| Abstract: | Objective:To investigate the effect of metoprolol on plasma aldosterone,myocardium fibrosis and reverse ventricular remodeling in rats with corgestive heart failure.Method:Male SD rats were randomly allocated to the Isopreternol(ISO)-induced chronic heart failure group(n=20)receiving two subcutaneous injections of 170mg ISO per kilogram of body and the healthy normal group(n=10)receiving two subcutaneous injections of 0.25ml normal saline.At 6th week,the LVEF was measured by echocardiogram,the remaining rat... |
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| Keywords: | Metoprolol CHF ALD Myocardial remodeling Rat |
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