雷公藤免疫抑制成分蒽醌的研究

目的 :研究雷公藤去皮根正丁醇提取部分中具有免疫抑制作用的化学成分。方法 :雷公藤去皮根水煎液经乙醇沉淀后的正丁醇提取部分 ,经硅胶和SephadexLH -20等柱分离纯化 ,并采用NMR、MS等波谱方法及与标准品对照薄层层析鉴定化学结构 ,免疫抑制活性测定。结果 :分离得到多个化合物 ,其中化合物1为蒽醌类成分大黄素 ,具有较强的免疫抑制作用。结论 :该化合物是首次从雷公藤属植物中分离得到。

Studies on Immunosuppressive Anthraquinone Constituents from Tripterygium wilfordii hook.f

OBJECTIVE:To study the immunosuppressive chemical constituents from the n-butanol extract of the debark root of Tripterygium wilfordii hook.f.METHODS:Several compounds were isolated from the n-butanol extract by columns of silica gels and Sephadex LH-20,their structures were identified by NMR,MS spectral analysis and comparing with standard substances on TLC,and the immunosuppressive activity was determined.RESULTS:One of the compounds was identified as emodin,an anthraquinone,it had marked immunosuppressive effect on animal.CONCLUSION:Emodin is obtained from the plants of Tripterygium wilfordii hook.f.for the first time.